Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ORAL CLONIDINE IN PATIENTS WITH ASTHMA - NO SIGNIFICANT EFFECT ON AIRWAY REACTIVITY
Autore:
FOXWORTH JW; REISZ GR; PYSZCZYNSKI DR; KNUDSON SM;
Indirizzi:
TRUMAN MED CTR W,DEPT MED,ROOM M4-133,2411 HOLMES ST KANSAS CITY MO 00000 UNIV MISSOURI,SCH MED KANSAS CITY MO 64108
Titolo Testata:
European Journal of Clinical Pharmacology
fascicolo: 1, volume: 48, anno: 1995,
pagine: 19 - 22
SICI:
0031-6970(1995)48:1<19:OCIPWA>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
ABNORMALITIES; METHACHOLINE; RESPONSES; HISTAMINE;
Keywords:
ASTHMA; CLONIDINE, AIRWAY RESISTANCE, METHACHOLINE, AIRWAY REACTIVITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
J.W. Foxworth et al., "ORAL CLONIDINE IN PATIENTS WITH ASTHMA - NO SIGNIFICANT EFFECT ON AIRWAY REACTIVITY", European Journal of Clinical Pharmacology, 48(1), 1995, pp. 19-22

Abstract

Fifteen patients with asthma were randomized into a double-blind, placebo controlled, crossover trial evaluating whether clonidine increased airway resistance. After meeting entry criteria [demonstration of 20% improvement in any two of the following pulmonary function tests after bronchodilator therapy: FVC, FEV(1), or forced expiratory flow over the mid-50 % of the vital capacity(FEF((25-75)))], patients were evaluated on two subsequent visits, receiving sequential doses of clonidine 0.1 mg (maximum cumulative dose 0.3 mg) or placebo in a random fashion. They returned to clinic after a 36-48 hour washout period at which time they received the opposite treatment. The end points were threedoses of clonidine or placebo, decrease in blood pressure to less than or equal to 90 mm mercury systolic, and/or < 70 mm mercury diastolic, or a 20 % fall in FEV(1). Airway reactivity was proved utilizing methacholine on each clinic visit, and blood pressures were monitored continuously during the study period. There were no significant differences in the provocative concentrations of methacholine inducing a 20 % fall in FEV(1) (PD20) between baseline (1.92), clonidine (1.10), and placebo (1.69). (Numbers in parentheses indicate PD20 values in cumulative dose units).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 19:04:20