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Titolo:
WHAT DOES MOS DO IN OOCYTES AND SOMATIC-CELLS
Autore:
SAGATA N;
Indirizzi:
KYUSHU UNIV,FAC SCI,DEPT BIOL,HAKOZAKI 6-10-1 FUKUOKA 81281 JAPAN
Titolo Testata:
BioEssays
fascicolo: 1, volume: 19, anno: 1997,
pagine: 13 - 21
SICI:
0265-9247(1997)19:1<13:WDMDIO>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTO-ONCOGENE PRODUCT; MAP KINASE KINASE; METAPHASE-II ARREST; XENOPUS-OOCYTES; CYCLIN-B; PROTOONCOGENE PRODUCT; MEIOTIC MATURATION; TRANSFORMING ACTIVITY; FROG OOCYTES; MOUSE EGGS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
70
Recensione:
Indirizzi per estratti:
Citazione:
N. Sagata, "WHAT DOES MOS DO IN OOCYTES AND SOMATIC-CELLS", BioEssays, 19(1), 1997, pp. 13-21

Abstract

Mos, a protein kinase, is specifically expressed and functions duringmeiotic maturation (or G(2)/M progression) of vertebrate oocytes. When expressed ectopically, however, it can also readily induce oncogenictransformation (or uncontrolled G(1)/S transitions) in somatic cells. In both of these cell types, Mos activates mitogen-activated protein kinase (MAPK), which seems largely to mediate its different functions in both oocyte maturation and cellular transformation, In oocyte maturation, the Mos-MAPK pathway probably serves to activate and stabilize M-phase promoting factor (MPF) (possibly by inhibiting some negative regulator(s) of this factor), while in cellular transformation, it seems to stabilize and activate the nuclear oncoprotein c-Fos as well as to induce transcription of its gene. Thus, the different functions of Mos in oocytes and somatic cells may arise chiefly from its different MAPK-mediated targets in the respective cell types. This review discusses the cellular basis that may enable Mos to act differently in oocytes and somatic cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 10:25:56