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Titolo:
INSULIN ATTENUATES NOREPINEPHRINE-INDUCED VENOCONSTRICTION - AN ULTRASONOGRAPHIC STUDY
Autore:
GROVER A; PADGINTON C; WILSON MF; SUNG BH; IZZO JL; DANDONA P;
Indirizzi:
SUNY BUFFALO,MILLARD FILLMORE HOSP,DEPT MED,3 GATES CIR BUFFALO NY 14209
Titolo Testata:
Hypertension
fascicolo: 4, volume: 25, anno: 1995,
parte:, 2
pagine: 779 - 784
SICI:
0194-911X(1995)25:4<779:IANV-A>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASCULAR SMOOTH-MUSCLE; BLOOD-PRESSURE; ANGIOTENSIN-II; HUMAN FOREARM; RESPONSIVENESS; HYPERTENSION; RESPONSES; VEIN;
Keywords:
INSULIN; GUANOSINE CYCLIC MONOPHOSPHATE; ULTRASONOGRAPHY; NOREPINEPHRINE; VEINS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
A. Grover et al., "INSULIN ATTENUATES NOREPINEPHRINE-INDUCED VENOCONSTRICTION - AN ULTRASONOGRAPHIC STUDY", Hypertension, 25(4), 1995, pp. 779-784

Abstract

To directly assess insulin-related venomotor changes objectively and quantitatively, we used a modified ultrasonographic technique to measure venous diameter. Ten healthy men and women were studied by use of an Acuson 128 XP ultrasonograph with a linear 7.5-MHz ultrasonographic transducer (sensitivity, +/-0.1 mm). Venous diameter was mea sured with the arm kept at 30 degrees elevation and with a pneumatic cuff abovethe elbow inflated at 40 mm Hg for the last 2 minutes of each 5-minute observation period. Norepinephrine was infused at incremental concentrations of 12.5, 25, 50, and 100 ng/min (75, 150, 300, and 600 pmol/min, respectively) for 5 minutes each. Maximal venoconstriction was achieved by the dose of 100 ng/min norepinephrine, which was then combined with insulin doses of 8, 16, 24, and 32 mu U/min (60, 120, 180, and 230 fmol/min, respectively) for 5 minutes each. In six different subjects, methylene blue, an inhibitor of guanylate cyclase, was infused simultaneously with 32 mu U/min insulin and 100 ng/min norepinephrine. Mean resting diameter of the vein (1.8+/-0.6 mm [mean+/-SD]) increased (to 3.0+/-1.0 mm) after cuff inflation. Incremental doses of norepinephrine caused highly reproducible dose-dependent decreases in venous diameter (to 1.8+/-0.6 mm, P<.001). Incremental doses of insulin, when combined with the maximum dose of norepinephrine, caused highly reproducible dose-dependent increases in mean venous diameter (P<.001) compared with norepinephrine alone. Methylene blue, which had no independenteffect on venous diameter, inhibited the venodilator effect of insulin (P<.05). Infusion of these substances caused no systemic changes in heart rate, blood pressure, or blood glucose. Modified venous ultrasonography can measure, in vivo, venomotor changes with hormones or drugsin doses that do not produce any systemic effects. Norepinephrine is a potent venoconstrictor whose local effects can be attenuated by insulin in normal subjects. Insulin-induced venodilation is blocked by methylene blue and is therefore probably cyclic guanylate monophosphate dependent.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/10/20 alle ore 11:29:16