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Titolo:
NASAL CYTOLOGICAL CHANGES FOLLOWING PHARMACOLOGICAL INTERVENTION
Autore:
MELTZER EO;
Indirizzi:
ALLERGY & ASTHMA MED GRP & RES CTR,9610 GRANITE RIDGE DR,SUITE B SAN DIEGO CA 92123
Titolo Testata:
Allergy
fascicolo: 23, volume: 50, anno: 1995, supplemento:, S
pagine: 15 - 20
SICI:
0105-4538(1995)50:23<15:NCCFPI>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEASONAL ALLERGIC RHINITIS; DAILY FLUTICASONE PROPIONATE; BECLOMETHASONE DIPROPIONATE; SPRAY; PRETREATMENT; HISTAMINE; CELLS;
Keywords:
ALLERGIC RHINITIS, SEASONAL, PERENNIAL; FLUTICASONE PROPIONATE AQUEOUS NASAL SPRAY; EOSINOPHILS; BASOPHILS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
E.O. Meltzer, "NASAL CYTOLOGICAL CHANGES FOLLOWING PHARMACOLOGICAL INTERVENTION", Allergy, 50(23), 1995, pp. 15-20

Abstract

Symptoms of allergic rhinitis are associated with increased numbers of inflammatory cells in the nasal mucosa. The effects of fluticasone propionate on the nasal mucosal cells of patients with symptomatic allergic rhinitis were evaluated in seven multicentre, double-blind, parallel-group, placebo-controlled, randomised studies. In three seasonal allergic rhinitis studies, significantly more patients receiving fluticasone propionate had a decrease in nasal eosinophils following treatment compared with patients receiving placebo. Similarly, more patients receiving fluticasone propionate had a decrease in nasal basophilic cells, but differences from placebo were not significant in all studies. Nearly identical results were observed in two 24-week perennial allergic rhinitis studies: significantly more patients receiving fluticasone propionate or beclomethasone dipropionate had a decrease in nasal eosinophils compared with patients receiving placebo. Furthermore, a higher percentage of patients receiving corticosteroids also had a decrease in the number of basophilic cells. In two separate seasonal allergic rhinitis studies, significantly more patients receiving fluticasone propionate had a decrease in nasal eosinophils compared with patients receiving terfenadine or astemizole, respectively. The decrease in nasal basophilic cells was also significantly greater with fluticasone propionate compared with astemizole. Inhibition of mediator release fromeosinophilic and basophilic cells has also been demonstrated in patients receiving fluticasone propionate compared with patients receiving antihistamines. The results of these studies suggest that the therapeutic benefits of fluticasone propionate aqueous nasal spray in the treatment of seasonal and perennial allergic rhinitis may be related to its ability to reduce nasal mucosal inflammatory cells and to inhibit local mediator activity.

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Documento generato il 05/12/20 alle ore 23:23:40