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Titolo:
TRANSPLACENTAL PASSAGE AND MILK EXCRETION OF IOBITRIDOL
Autore:
BOURRINET P; DENCAUSSE A; HAVARD P; VIOLAS X; BONNEMAIN B;
Indirizzi:
LAB GUERBET,BP 50400 F-95943 ROISSY FRANCE LAB GUERBET AULNAY SOUS BOIS FRANCE
Titolo Testata:
Investigative radiology
fascicolo: 3, volume: 30, anno: 1995,
pagine: 156 - 158
SICI:
0020-9996(1995)30:3<156:TPAMEO>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
BREAST-MILK;
Keywords:
IOBITRIDOL; MILK EXCRETION; TRANSPLACENTAL PASSAGE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
9
Recensione:
Indirizzi per estratti:
Citazione:
P. Bourrinet et al., "TRANSPLACENTAL PASSAGE AND MILK EXCRETION OF IOBITRIDOL", Investigative radiology, 30(3), 1995, pp. 156-158

Abstract

RATIONALE AND OBJECTIVES. Iobitridol, a new nonionic, low-osmolality urographic and angiographic contrast medium, is a marker of extracellular fluid. Excretion of iobitridol in goat's milk and transplacental passage in the gestating rabbit were evaluated compared with iohexol. METHODS. Both products were determined in biologic samples by two analytic methods: ultraviolet spectrometry (milk) and high-pressure liquid chromatography (maternal and fetal blood and amniotic fluid). RESULTS. Excretion in the milk represents 0.7% of the administered dose for iobitridol and 1.6% for iohexol. Transplacental passage is nonexistent. Iobitridol and iohexol behave in a similar manner. CONCLUSIONS. These preclinical results allow more effective prediction of the safety of iobitridol in pregnant or lactating women. However, precautions for usemust be respected in the absence of specific studies in this population group.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 07:56:11