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Titolo:
SULFHYDRYL-GROUP CONTROL OF SODIUM-LITHIUM COUNTERTRANSPORT KINETICS - A MEMBRANE-PROTEIN CONTROL ABNORMALITY IN ESSENTIAL-HYPERTENSION
Autore:
THOMAS TH; RUTHERFORD PA; WEST IC; WILKINSON R;
Indirizzi:
FREEMAN RD HOSP,DEPT MED NEPHROL,NEPHROL LABS,PODIUM LEVEL 4,HIGH HEATON NEWCASTLE TYNE NE7 7DN TYNE & WEAR ENGLAND UNIV NEWCASTLE UPON TYNE,DEPT BIOCHEM & GENET NEWCASTLE TYNE TYNE & WEAR ENGLAND
Titolo Testata:
European journal of clinical investigation
fascicolo: 4, volume: 25, anno: 1995,
pagine: 235 - 240
SICI:
0014-2972(1995)25:4<235:SCOSCK>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSPORT; CELLS;
Keywords:
ERYTHROCYTE MEMBRANE; ESSENTIAL HYPERTENSION; N-ETHYLMALEIMIDE; SODIUM-LITHIUM COUNTERTRANSPORT; SULFHYDRYL GROUP; TRANSPORT KINETICS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
12
Recensione:
Indirizzi per estratti:
Citazione:
T.H. Thomas et al., "SULFHYDRYL-GROUP CONTROL OF SODIUM-LITHIUM COUNTERTRANSPORT KINETICS - A MEMBRANE-PROTEIN CONTROL ABNORMALITY IN ESSENTIAL-HYPERTENSION", European journal of clinical investigation, 25(4), 1995, pp. 235-240

Abstract

Erythrocyte sodium-lithium countertransport (SLC) is an obligatorily coupled equimolar exchange of intracellular sodium or lithium with extracellular sodium or lithium. SLC is partially inhibited by N-ethylmaleimide (NEM) but only when a transported ion (sodium or lithium) is present in the extracellular medium. In essential hypertensive patients with a strong family history of hypertension the Km of SLC for extracellular sodium was lower and Vmax tended to be higher than in normal controls, but the ratio Vmax/Km gave a much clearer distinction between the two groups. After NEM treatment, the remaining SLC activity in normal individuals had a lower Vmax and Km for sodium but Vmax/Km was notaffected. In essential hypertensives the remaining SLC activity afterNEM again had lowered Vmax and Km but in these patients the Vmax/Km was much lower than in untreated erythrocytes and was then the same as in normal controls. On the assumption that NEM reacts with a -SH groupon a membrane protein that regulates SLC, and that the ratio Vmax/Km reflects a rate constant for binding extracellular sodium to the unloaded carrier, the results suggest that (a) essential hypertensives havean increased rate of sodium binding to the transporter and (b) this is due to abnormal behaviour of a membrane -SH group.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/21 alle ore 16:52:15