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Titolo:
INTERACTION BETWEEN FLUMAZENIL AND THE ANESTHETIC EFFECTS OF HEXOBARBITAL IN THE RAT
Autore:
KORKMAZ S; LJUNGBLAD E; WAHLSTROM G;
Indirizzi:
UMEA UNIV,DEPT PHARMACOL S-90187 UMEA SWEDEN
Titolo Testata:
Brain research
fascicolo: 2, volume: 676, anno: 1995,
pagine: 371 - 377
SICI:
0006-8993(1995)676:2<371:IBFATA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTAGONISTS RO 15-1788; BENZODIAZEPINE ANTAGONIST; ANXIOGENIC ACTION; CNS-SENSITIVITY; MIDAZOLAM; RO-15-1788; AGONIST; HALOTHANE; BEHAVIOR; EEG;
Keywords:
FLUMAZENIL; DIAZEPAM; LORAZEPAM; INTERACTION; HEXOBARBITAL ANESTHESIA THRESHOLD; ELECTROENCEPHALOGRAPHIC THRESHOLD TECHNIQUE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
S. Korkmaz et al., "INTERACTION BETWEEN FLUMAZENIL AND THE ANESTHETIC EFFECTS OF HEXOBARBITAL IN THE RAT", Brain research, 676(2), 1995, pp. 371-377

Abstract

Interaction between flumazenil, a substance regarded mainly as a benzodiazepine antagonist, and an intravenous anesthetic barbiturate, hexobarbital, was investigated by using an electroencephalography threshold test in male rats. Flumazenil 10 mg/kg given as pretreatment reducedthe threshold dose of hexobarbital approximately 20% indicating a synergistic interaction. Similar effects were obtained with the agonists,diazepam 20 mg/kg and lorazepam 2 mg/kg. Dose-response curve for flumazenil (2.5-10 mg/kg) was determined with the same technique and hexobarbital concentrations were analysed in serum and several brain regions at the threshold by high pressure liquid chromatography. Flumazenil 10 mg/kg pretreated group showed a different pattern of distribution of hexobarbital into the tested brain regions indicating a pharmacokinetic interaction. Low concentrations of hexobarbital in the brainstem which were negatively correlated with the dose of flumazenil indicate apharmacodynamic interaction which could be due to a partial agonisticintrinsic activity of flumazenil, usually seen at much higher doses.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 08:07:00