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Titolo:
ACTIVATING MUTATIONS OF RAS FAMILY GENES IN PROSTATIC-CANCER
Autore:
KIARIS H; ELIOPOULOS AG; SIVRIDIS E; ERGAZAKI M; SPANDIDOS DA;
Indirizzi:
NATL HELLEN RES FDN,INST BIOL RES & BIOTECHNOL,48 VAS CONSTANTINOU AVE GR-11635 ATHENS GREECE NATL HELLEN RES FDN,INST BIOL RES & BIOTECHNOL GR-11635 ATHENS GREECE UNIV CRETE,SCH MED IRAKLION GREECE UNIV BIRMINGHAM,SCH MED,CRC,INST CANC STUDIES BIRMINGHAM B15 2TH W MIDLANDS ENGLAND DEMOCRITUS UNIV THRACE,SCH MED ALEXANDROUPOLIS GREECE
Titolo Testata:
Oncology Reports
fascicolo: 3, volume: 2, anno: 1995,
pagine: 427 - 430
SICI:
1021-335X(1995)2:3<427:AMORFG>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARCINOMA; FREQUENCY; ONCOGENE;
Keywords:
K-RAS; N-RAS; H-RAS; PCR; RFLP; PROSTATIC CANCER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
H. Kiaris et al., "ACTIVATING MUTATIONS OF RAS FAMILY GENES IN PROSTATIC-CANCER", Oncology Reports, 2(3), 1995, pp. 427-430

Abstract

ras family genes (H-, K- and N-ras) encode for a 21 kD membrane protein which possesses GTPase activity and participates in a signal transduction pathway. Activating mutations of the ras family genes occur at codons 12, 13 and 61 and have been detected in a variety of human tumours, including colonic, bladder and pancreatic cancers. Prostatic cancer is among the most common malignancies throughout the world and a major cause of death from cancer in males. Data reported on the implication of the ras family genes in the development of the disease are conflicting. The aim of this study was to determine the incidence of mutations at codon 12 of H-ras, codon 12 of K-ras and codon 61 of N-ras proto-oncogenes, in a Greek population with prostatic cancer. Our analysis revealed that 4 out of 20 (20%) samples harboured a K-ras codon 12 point mutation, 1 out of 20 (5%) specimens contained mutations at codon12 of the H-ras and 1 out of 20 (5%) at codon 61 of the N-ras, indicating a role for the ras genes in the development of the disease.

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Documento generato il 12/07/20 alle ore 06:03:27