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Titolo:
SOMATOSTATIN AND LEU-ENKEPHALIN IN THE RAT AUDITORY BRAIN-STEM DURINGFETAL AND POSTNATAL-DEVELOPMENT
Autore:
KUNGEL M; FRIAUF E;
Indirizzi:
UNIV TUBINGEN,MORGENSTELLE 28 D-72076 TUBINGEN GERMANY
Titolo Testata:
Anatomy and embryology
fascicolo: 5, volume: 191, anno: 1995,
pagine: 425 - 443
SICI:
0340-2061(1995)191:5<425:SALITR>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUPERIOR OLIVARY COMPLEX; CENTRAL-NERVOUS-SYSTEM; POSTEROVENTRAL COCHLEAR NUCLEUS; ENDOGENOUS OPIOID SYSTEMS; CONTAINING NEURON SYSTEM; TRANSIENT EXPRESSION; SYMPATHETIC NEURONS; LATERAL LEMNISCUS; CALCIUM CURRENTS; GUINEA-PIG;
Keywords:
IMMUNOCYTOCHEMISTRY; NEUROPEPTIDE; TRANSIENT; REGRESSIVE EVENTS; SUPERIOR OLIVARY COMPLEX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
98
Recensione:
Indirizzi per estratti:
Citazione:
M. Kungel e E. Friauf, "SOMATOSTATIN AND LEU-ENKEPHALIN IN THE RAT AUDITORY BRAIN-STEM DURINGFETAL AND POSTNATAL-DEVELOPMENT", Anatomy and embryology, 191(5), 1995, pp. 425-443

Abstract

A transient expression of the neuropeptide somatostatin has been described in several brain areas during early ontogeny and several opioid peptides, such as leu-enkephalin, have also been found in the brain atthis stage in development. It is therefore believed that somatostatinand leu-enkephalin may play a role in neural maturation. The aim of the present study was to describe the spatiotemporal pattern of somatostain and leu-enkephalin immunoreactivity in the auditory brainstem nuclei of the developing rat and to correlate it with other developmentalevents. In order to achieve this goal, we applied peroxidase-antiperoxidase immunocytochemistry to rat brains between embryonic day (E) 17 and adulthood. Somatostatin immunoreactivity (SIR) was found in all nuclei of the auditory brainstem, yet it was temporally restricted in most nuclei. SIR appeared prenatally and reached maximum levels around postnatal day (P) 7, when great numbers of immunoreactive neurons were present in the ventral cochlear nucleus (VCN) and in the lateral lemniscus. At that time relatively low numbers of cells were labeled in thedorsal cochlear nucleus, the lateral superior olive (LSO), and the inferior colliculus (IC). During the same period, when somata in the VCNwere somatostatin-immunoreactive (SIR), a dense network of labeled fibers was also present in the LSO, the medial superior olive (MSG), andthe medial nucleus of the trapezoid body (MNTB). As these nuclei receive direct input from VCN neurons, and as the distribution and morphology of the somatostatinergic fibers in the superior olivary complex (SOC) was like that of axons from VCN neurons, these findings suggest a transient somatostatinergic connection within the auditory system. Aside from the LSO, MSG, and MNTB, labeled fibers were found to a smallerextent in all other auditory brainstem nuclei. After P7, the SIR decreased and only a few immunoreactive elements were found in the adult auditory brainstem nuclei, indicating that somatostatin is transiently expressed in the rat auditory brainstem. Leu-enkephalin immunoreactivity showed a lower number and weaker intensity of labeled structures ascompared to SIR, with E18 being the earliest day at which labeled fibers appeared in the SOC. At birth, immunoreactive fibers were also present in the cochlear nuclear complex and in the IC. Leu-enkephalin immunoreactive somata were found only after P12 in the CN and after P16 in the IC. Leu-enkephalin immunoreactivity was not transient, but increased progressively with age until about P21, when the adult levels were reached. Our results demonstrate somatostatinergic and leu-enkephalinergic inputs onto auditory brainstem neurons during perinatal life, i.e., during a period when the processes of synapse maturation occur. It is thus likely that both neuropeptides may influence the developmentof synaptic connections in the auditory brainstem.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 14:08:42