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Titolo:
THE SEGMENTAL PRECISION OF THE MOTOR PROJECTION TO THE INTERCOSTAL MUSCLES IN THE DEVELOPING CHICKEN-EMBRYO - A DIFFERENTIAL LABELING STUDYUSING FLUORESCENT TRACERS
Autore:
STIRLING RV; LIESTOL K; SUMMERBELL D; GLOVER JC;
Indirizzi:
UNIV OSLO,INST BASIC MED SCI,DEPT PHYSIOL,PB 1103 BLINDERN N-0317 OSLO NORWAY UNIV OSLO,INST BASIC MED SCI,DEPT PHYSIOL N-0317 OSLO NORWAY OPEN UNIV,DEPT BIOL MILTON KEYNES MK7 6AA BUCKS ENGLAND UNIV OSLO,DEPT COMP SCI N-0317 OSLO NORWAY NATL INST MED RES LONDON NW7 1AA ENGLAND
Titolo Testata:
Anatomy and embryology
fascicolo: 5, volume: 191, anno: 1995,
pagine: 397 - 406
SICI:
0340-2061(1995)191:5<397:TSPOTM>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVOUS-SYSTEM; SPINAL-CORD; CELL-DEATH; HIND LIMB; ORGANIZATION; MOTONEURONS; NEURONS; POOLS; DYES;
Keywords:
MOTOR PROJECTION; CELL DEATH; AVIAN EMBRYO; FLUORESCENT DEXTRAN AMINES; FLUORESCENT LATEX MICROSPHERES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
R.V. Stirling et al., "THE SEGMENTAL PRECISION OF THE MOTOR PROJECTION TO THE INTERCOSTAL MUSCLES IN THE DEVELOPING CHICKEN-EMBRYO - A DIFFERENTIAL LABELING STUDYUSING FLUORESCENT TRACERS", Anatomy and embryology, 191(5), 1995, pp. 397-406

Abstract

Each skeletal muscle in the vertebrate is innervated by a group of motoneurons called a motoneuron pool. Retrograde labelling of single motoneuron pools has suggested that the arrangement of motoneuron pools innervating different limb muscles does not change during the embryonicperiod when more than 50% of the motoneurons die. In this study we retrogradely labelled neighbouring intercostal motoneuron pools differentially with latex microspheres or dextran amines coupled to fluorescent dyes. We then mapped the positions of the differentially labelled motoneurons in whole-mount preparations using a computer-aided drawing system. While the intercostal motoneuron pools are clearly segregated even at early stages, there is some intermingling at the rostral and caudal ends. We used a logistic regression to determine the extent of segmental overlap, and to facilitate a quantitative comparison of the overlap at different stages. Statistical analysis shows that the overlap(expressed as the percentage of the length of the overlapping motoneuron pools) decreases modestly during the period of motoneuron death. Computer simulations suggest that this decrease does not result from random motoneuron death alone; one alternative possibility is selective death of motoneurons in the overlap zone. Occasional ''rogue'' motoneurons, that is, motoneurons of one pool that scatter into the neighbouring pool, are still present at the end of the period of cell death, representing a potential source of ''noise'' in the establishment of segmental patterns of connectivity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 04:56:29