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Titolo:
SWISS POPULATION-DATA AND FORENSIC EFFICIENCY VALUES ON 3 TETRAMERIC SHORT TANDEM REPEAT LOCI, HUMTHO1, TPOX, AND CSF1PO, DERIVED USING A STR MULTIPLEX SYSTEM
Autore:
HOCHMEISTER MN; BUDOWLE B; SCHUMM JW; SPRECHER CJ; BORER UV; DIRNHOFER R;
Indirizzi:
INST MED LEGALE,BUHLSTR 20 CH-3012 BERN SWITZERLAND FED BUR INVEST ACAD,CTR FORENS SCI RES & TRAINING,DIV LAB QUANTICO VA22135 PROMEGA CORP MADISON WI 53711
Titolo Testata:
International journal of legal medicine
fascicolo: 5, volume: 107, anno: 1995,
pagine: 246 - 249
SICI:
0937-9827(1995)107:5<246:SPAFEV>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENETIC-VARIATION; ALLELES; DNA; HETEROZYGOSITY; POLYMORPHISM; DISTANCE; NUMBER;
Keywords:
DNA-STRS; HUMTH01; TPOX; CSF1PO-POLYMARKER; POPULATION GENETICS; SWITZERLAND; HARDY-WEINBERG EXPECTATIONS; LINKAGE EQUILIBRIUM; PCR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
M.N. Hochmeister et al., "SWISS POPULATION-DATA AND FORENSIC EFFICIENCY VALUES ON 3 TETRAMERIC SHORT TANDEM REPEAT LOCI, HUMTHO1, TPOX, AND CSF1PO, DERIVED USING A STR MULTIPLEX SYSTEM", International journal of legal medicine, 107(5), 1995, pp. 246-249

Abstract

Allele and genotype frequencies for 3 tetrameric short tandem repeat loci were determined in a Swiss population sample (n = 100) using the GenePrint STR Multiplex System, electrophoresis of the PCR products inDNA sequencing gels and subsequent detection of allelic fragments by silver staining. The loci are HUMTHO1, TPOX, and CSF1PO. The observed heterozygosities are 83.0%, 60.0%, and 72.0%, respectively. The discrimination power determined for the individual loci is 0.914, 0.780, and0.860, respectively, and the combined discrimination power for the tripler is 0.997. All loci meet Hardy Weinberg expectations and after Bonferroni correction there was no evidence that the population sample deviates from expectations of independence. Moreover, independence of alleles at these STR loci with other PCR-based loci derived from the same Swiss population sample, previously reported, were considered. These loci were DQA1, LDLR, GYPA, HBGG, D7S8, GC and D1S80. Again, after Bonferroni correction there was no evidence that the population sample deviates from expectations of independence among alleles at the 10 different PCR-based loci. Thus, the allelic frequency data can be used inhuman identity testing to estimate the frequency of a multiple PCR-based DNA profile in the Swiss population.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/11/20 alle ore 20:29:30