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Titolo:
STUDY OF THE BLOOD-AQUEOUS BARRIER IN CHOROIDAL MELANOMA
Autore:
CASTELLA AP; BERCHER L; ZOGRAFOS L; EGGER E; HERBORT CP;
Indirizzi:
LA SOURCE EYE CTR,2 AVE BERGIERES CH-1004 LAUSANNE SWITZERLAND LA SOURCE EYE CTR CH-1004 LAUSANNE SWITZERLAND PAUL SCHERRER INST,SWISS NATL INST NUCL RES VILLIGEN SWITZERLAND UNIV LAUSANNE,HOSP JULES GONIN,DEPT OPHTHALMOL LAUSANNE SWITZERLAND
Titolo Testata:
British journal of ophthalmology
fascicolo: 4, volume: 79, anno: 1995,
pagine: 354 - 357
SICI:
0007-1161(1995)79:4<354:SOTBBI>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
UVEAL MALIGNANT-MELANOMA; ANTERIOR UVEITIS EAAU; FLARE-CELL METER; INFLAMMATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
A.P. Castella et al., "STUDY OF THE BLOOD-AQUEOUS BARRIER IN CHOROIDAL MELANOMA", British journal of ophthalmology, 79(4), 1995, pp. 354-357

Abstract

Aims-Aqueous hare was used to determine the frequency and amount of blood-aqueous barrier breakdown and correlate it with tumour variables. Methods-Aqueous flare was analysed prospectively by laser flare photometry in 139 consecutive patients seen in the oncology unit for choroidal melanoma. Both eyes of patients were examined with a laser hare cell meter in a standard fashion. Results-Mean flare difference between healthy and tumour eyes was 3.01 (SD 2.5) photons per millisecond (ph/ms) in 32 cases of small melanomas (p<0.0001), 10.74 (13.9) ph/ms in 92 cases of medium and large melanomas (p<0.0001), and 19.23 (11.8) ph/ms in 15 cases of very large melanomas (p<0.0001). This mean differential flare was significantly higher in medium and large than in small melanomas (p<0.002) and in very large melanomas than in medium and large melanomas (p<0.028). A difference of greater than or equal to 7 ph/ms between affected and healthy eyes was noted in 70 of 139 melanomas (50.4%). It was found in 3/32 small melanomas (9.4%), in 53/92 medium and large melanomas (57.6%), and in 14/15 very large melanomas (93.3%). Conclusion-Multiple linear regression analysis showed that flare was most strongly correlated with tumour volume (r=0.43; p<0.0001) and tumour height (r=041; p<0.0008).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 07:30:34