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Titolo:
DOWN-REGULATION OF MHC CLASS-I EXPRESSION DUE TO INTERFERENCE WITH P105-NF-KAPPA-B1 PROCESSING BY AD12E1A
Autore:
SCHOUTEN GJ; VANDEREB AJ; ZANTEMA A;
Indirizzi:
LEIDEN UNIV,SYLVIUS LABS,MOLEC CARCINOGENESIS LAB,WASSENAARSEWEG 72 2333 AL LEIDEN NETHERLANDS
Titolo Testata:
EMBO journal
fascicolo: 7, volume: 14, anno: 1995,
pagine: 1498 - 1507
SICI:
0261-4189(1995)14:7<1498:DOMCED>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
NF-KAPPA-B; TRANSFORMED RAT-CELLS; DNA-BINDING SUBUNIT; MEDIATED SIGNAL TRANSDUCTION; ENHANCER-LIKE SEQUENCES; GENE-EXPRESSION; TRANSCRIPTION FACTOR; NEGATIVE REGULATION; ADENOVIRUS-TYPE-12 E1A; ONCOGENE PRODUCT;
Keywords:
E1A; H2TF1; MHC CLASS I; NF-KAPPA-B; TRANSCRIPTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
69
Recensione:
Indirizzi per estratti:
Citazione:
G.J. Schouten et al., "DOWN-REGULATION OF MHC CLASS-I EXPRESSION DUE TO INTERFERENCE WITH P105-NF-KAPPA-B1 PROCESSING BY AD12E1A", EMBO journal, 14(7), 1995, pp. 1498-1507

Abstract

We have previously demonstrated that expression of major histocompatibility complex (MHC) class I genes is repressed in baby rat kidney cells transformed by early region 1 of oncogenic adenovirus type 12 (Ad12E1). Reduced expression of MHC class I antigens contributes to the escape of Ad12-transformed cells from T-cell-mediated immune surveillanceand to tumour induction. In this study, we show that repression of MHC class I expression by Ad12E1A is mediated via the N2TF1 element of the MHC class I promoter. This element binds NF kappa B and KBF1, two factors which play a major role in the regulation of MHC class I expression in vivo. In extracts from Ad12E1-transformed cells, binding of KBF1 and NF kappa B to the H2TF1 element is decreased. This is caused byreduced production of p50-NF kappa B1, the 50 kDa subunit shared by KBF1 and NF kappa B, due to interference with p105-NF kappa B1 processing by Ad12-13S-E1A protein. Overexpression of the p105-NF kappa B1 cDNA, or of a truncated p105-NF kappa B1 cDNA that codes for p50-NF kappaB1, restores MHC class I expression in Ad12E1-transformed cells. These data demonstrate that downregulation of MHC class I expression in Ad12E1-transformed cells is due to interference with processing of p105-NF kappa B1 by the Ad12-13S-E1A protein.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 19:24:40