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Titolo:
DILATATION OF THE BASILAR ARTERY IN RESPONSE TO SELECTIVE ACTIVATION OF ENDOTHELIN-B RECEPTORS IN-VIVO
Autore:
KITAZONO T; HEISTAD DD; FARACI FM;
Indirizzi:
UNIV IOWA,COLL MED,DEPT INTERNAL MED,DIV CARDIOVASC IOWA CITY IA 52242 UNIV IOWA,COLL MED,DEPT INTERNAL MED,DIV CARDIOVASC IOWA CITY IA 52242 UNIV IOWA,COLL MED,DEPT PHARMACOL IOWA CITY IA 52242 UNIV IOWA,COLL MED,CTR CARDIOVASC IOWA CITY IA 52242 UNIV IOWA,COLL MED,CTR AGING IOWA CITY IA 52242 VET ADM MED CTR IOWA CITY IA 00000
Titolo Testata:
The Journal of pharmacology and experimental therapeutics
fascicolo: 1, volume: 273, anno: 1995,
pagine: 1 - 6
SICI:
0022-3565(1995)273:1<1:DOTBAI>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-VESSELS; CELLULAR BIOLOGY; SMOOTH-MUSCLE; ETA RECEPTOR; POTENT; ANTAGONISTS; IRL-1620; CLONING; AGONIST; CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
T. Kitazono et al., "DILATATION OF THE BASILAR ARTERY IN RESPONSE TO SELECTIVE ACTIVATION OF ENDOTHELIN-B RECEPTORS IN-VIVO", The Journal of pharmacology and experimental therapeutics, 273(1), 1995, pp. 1-6

Abstract

The objective of this study was to examine effects of activation of endothelin (ET) B receptors on tone of the basilar artery in vivo. By using a cranial window in anesthetized rats, we examined the effects ofIRL 1620, a selective ET(B) receptor agonist, on diameter of the basilar artery. Under control conditions, diameter of the basilar artery was 214 +/- 6 mu m (mean +/- S.E.). Topical application of IRL 1620 (10(-8) mol/l) for 4 min dilated the basilar artery by 30 +/- 4%. Marked desensitization of vasodilator responses was observed in response to asecond application of IRL 1620, but not acetylcholine, which indicates a homologous nature of desensitization. REA/001, an ET(A)/ET(B), receptor antagonist, abolished IRL 1620-induced dilatation of the basilarartery. BQ 123, a selective ET(A) receptor antagonist, inhibited constriction in response to ET-1, but did not affect dilator responses of the basilar artery to IRL 1620. Both N-G-nitro-L-arginine methyl esterand N-G-nitro-L-arginine, inhibitors of nitric oxide synthase, produced marked inhibition of dilator responses of the basilar artery to IRL1620 without inhibiting vasodilator responses to sodium nitroprusside. Indomethacin did not inhibit vasodilatation in response to IRL 1620. These findings suggest that activation of ET(B) receptors produces dilatation of the basilar artery in vivo. Dilator responses of the basilar artery to activation of ET(B) receptors are dependent on productionof nitric oxide.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 12:43:37