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Titolo:
CORRELATION OF COLD PRESSOR AND FLOW-MEDIATED BRACHIAL-ARTERY DIAMETER RESPONSES WITH THE PRESENCE OF CORONARY-ARTERY DISEASE
Autore:
CORRETTI MC; PLOTNICK GD; VOGEL RA;
Indirizzi:
UNIV MARYLAND HOSP,DIV CARDIOL,22 S GREENE ST,ROOM N3W77 BALTIMORE MD21201 UNIV MARYLAND,SCH MED,DEPT MED,DIV CARDIOL BALTIMORE MD 21201
Titolo Testata:
The American journal of cardiology
fascicolo: 12, volume: 75, anno: 1995,
pagine: 783 - 787
SICI:
0002-9149(1995)75:12<783:COCPAF>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIUM-DEPENDENT DILATION; FOREARM RESISTANCE VESSELS; BLOOD-FLOW; RISK-FACTORS; DYSFUNCTION; HUMANS; ATHEROSCLEROSIS; ACETYLCHOLINE; VASODILATION; VASOMOTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
M.C. Corretti et al., "CORRELATION OF COLD PRESSOR AND FLOW-MEDIATED BRACHIAL-ARTERY DIAMETER RESPONSES WITH THE PRESENCE OF CORONARY-ARTERY DISEASE", The American journal of cardiology, 75(12), 1995, pp. 783-787

Abstract

Flow-mediated brachial and coronary artery vasoactivity are abnormal in patients with coronary artery disease (CAD) and cardiac risk factors, Cold presser coronary artery vasoactivity is abnormal in patients with CAD, but brachial artery responses have not been studied. This study assesses whether cold presser and flow-mediated brachial artery vasoactivity correlate independently with the presence of CAD, We studied50 men (27 who were clinically normal, 23 with angiographically proven CAD) aged 23 to 59 years. With use of 7.5 MHz ultrasound, we measured brachial artery diameter and Doppler flew velocity at baseline, during contralateral ice water hand immersion (cold presser), after 5 minutes of ipsilateral blood pressure cuff occlusion (flow-mediated), and after nitroglycerin administration. During cold presser stimulation, mean brachial artery diameter increased 0.36 +/- 2.93% in normal subjects but decreased 2.38 +/- 3.32% in the CAD subjects (p = 0.006). Mean flow-mediated diameter increased 9.11 +/- 6.01% and 6.58 +/- 7.50% in normal and CAD subjects, respectively (p = NS), Responses to sublingual nitroglycerin were the same in the 2 groups, Multiple stepwise regression analysis revealed that cold presser vasoactivity was found to correlate with smoking status (p = 0.0002) and the presence of CAD (p = 0.04). In the 32 nonsmokers undergoing assessment, only the presence of CAD correlated with cold presser vasoactivity (p = 0.02), The associations of brachial artery vasoactivity with cardiac risk factors and CAD appear to be stimulus-dependent. Cold presser vasoactivity correlates more closely with the presence of CAD than does flow-mediated vasoactivity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 11:48:18