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Titolo:
D-2 RECEPTOR BLOCKADE BY FLUNARIZINE AND CINNARIZINE EXPLAINS EXTRAPYRAMIDAL SIDE-EFFECTS - A SPECT STUDY
Autore:
BRUCKE T; WOBER C; PODREKA I; WOBERBINGOL C; ASENBAUM S; AULL S; WENGER S; ILIEVA D; HARASKOVANDERMEER C; WESSELY P; DEECKE L;
Indirizzi:
UNIV VIENNA,NEUROL KLIN,WAHRINGERGURTEL 18-20 A-1090 VIENNA AUSTRIA
Titolo Testata:
Journal of cerebral blood flow and metabolism
fascicolo: 3, volume: 15, anno: 1995,
pagine: 513 - 518
SICI:
0271-678X(1995)15:3<513:DRBBFA>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; DYNAMIC SPECT; DOPAMINE D2; NEUROLEPTICS; PARKINSONISM; DEPRESSION; BRAIN; DEATH; TIME; AGE;
Keywords:
CINNARIZINE; DOPAMINE D-2 RECEPTORS; EXTRAPYRAMIDAL SIDE EFFECTS; FLUNARIZINE; IODOBENZAMIDE; SPECT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
T. Brucke et al., "D-2 RECEPTOR BLOCKADE BY FLUNARIZINE AND CINNARIZINE EXPLAINS EXTRAPYRAMIDAL SIDE-EFFECTS - A SPECT STUDY", Journal of cerebral blood flow and metabolism, 15(3), 1995, pp. 513-518

Abstract

Twenty-six patients under treatment with the calcium channel blockersflunarizine (Fz) or cinnarizine (Cz) were examined with single-photonemission computed tomography using [I-123]iodobenzamide as a ligand. The striatal dopamine D-2 receptor-binding potential was determined and found to be reduced by 14 to 63% (39.5 +/- 15.0%; p < 0.0001) in patients compared with age-matched control values. This reduction was larger in 12 patients with extrapyramidal symptoms and was only slowly reversible after discontinuation of treatment. Patients treated for >6 months had significantly larger reductions than patients treated for a shorter period. Parkinsonian symptoms were only seen in patients olderthan 50 years. Our findings prove a neuroleptic-like action of Fz andCz, which seems to be the major reason for their extrapyramidal side effects. Older age and long-term treatment are predisposing factors for these effects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/11/18 alle ore 03:10:29