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Titolo:
DIABETES-MELLITUS AND ECHOCARDIOGRAPHIC LEFT-VENTRICULAR FUNCTION IN FREE-LIVING ELDERLY MEN AND WOMEN - THE CARDIOVASCULAR HEALTH STUDY
Autore:
LEE M; GARDIN JM; LYNCH JC; SMITH VE; TRACY RP; SAVAGE PJ; SZKLO M; WARD BJ;
Indirizzi:
GEN MED INVEST CLIN,2000 STOCKTON BLVD,STE 100 SACRAMENTO CA 95817 UNIV CALIF DAVIS,DEPT GEN MED DAVIS CA 95616 UNIV CALIF IRVINE,DEPT MED,DIV CARDIOL IRVINE CA 92717 UNIV WASHINGTON,DEPT BIOSTAT SEATTLE WA 98195 ALBANY MED COLL,DIV CARDIOL ALBANY NY 12208 UNIV VERMONT,SCH MED,DEPT PATHOL BURLINGTON VT 05405 UNIV VERMONT,SCH MED,DEPT BIOCHEM BURLINGTON VT 05405 NHLBI,DIV EPIDEMIOL & CLIN APPLICAT BETHESDA MD 20892 JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH BALTIMORE MD 00000
Titolo Testata:
The American heart journal
fascicolo: 1, volume: 133, anno: 1997,
pagine: 36 - 43
SICI:
0002-8703(1997)133:1<36:DAELFI>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIASTOLIC FUNCTION; DOPPLER ECHOCARDIOGRAPHY; TRANSMITRAL FLOW; HEART; MASS; DISEASE; CARDIOMYOPATHY; AGE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
M. Lee et al., "DIABETES-MELLITUS AND ECHOCARDIOGRAPHIC LEFT-VENTRICULAR FUNCTION IN FREE-LIVING ELDERLY MEN AND WOMEN - THE CARDIOVASCULAR HEALTH STUDY", The American heart journal, 133(1), 1997, pp. 36-43

Abstract

This report describes the relation among diabetes, blood pressure, and prevalent cardiovascular disease, and echocardiographically measuredleft ventricular mass and filling (transmitral valve flow) velocitiesin the Cardiovascular Health Study, a cohort of 5201 men and women greater than or equal to 65 years of age. Ventricular septal and left posterior wall thicknesses were greater in diabetic than in nondiabetic subjects, showing a significant linear trend (p = 0.025 for ventricular septal thickness in both sexes combined, p = 0.002 for posterior wall thickness) with increased duration of diabetes. Increased wall thickness of the ventricular septum or the left posterior wall was not associated with prevalent coronary heart disease (CHD) in the cohort. Increased left ventricular mass was associated with diabetic persons not reporting CHD and with all subjects with CHD regardless of glucose tolerance status. After adjusting for body weight, blood pressure, heart rate, and prevalent coronary or cerebrovascular disease, diabetes (as measured by glucose level, insulin use, oral hypoglycemic use, and a positive history of diabetes before baseline examination) remained an independent predictor of increased left ventricular mass among men and women (174.2 gm in diabetic men vs 169.8 gm in normal men, 138.2 gm in diabetic women vs 134.0 gm in normal women, p = 0.043 for both sexes combined). Both early and late diastolic transmitral peak Row velocities were higher with increased duration of diabetes, but the calculated ratio of the early peak flow velocity to the late velocity (E/A ratio)did not differ significantly between subjects with historical diabetes and those with normal fasting glucose (both genders combined, p = 0.190). Glucose level, insulin use, oral hypoglycemic use, and a positive history of diabetes before baseline examination were significant independent predictors of the late transmitral peak flow velocity and itsintegrated Row-velocity curve but not for the integral of the early peak Row velocity or the E/A ratio. Diabetes is associated with abnormal left ventricular structure and function in elderly persons. This association persists after adjustment for body weight, blood pressure, heart rate, and reported coronary or cerebrovascular disease.

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Documento generato il 28/11/20 alle ore 18:44:28