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Titolo:
GIANT LAMBL EXCRESCENCES - AN UNUSUAL SOURCE OF CEREBRAL EMBOLISM
Autore:
NIGHOGHOSSIAN N; DEREX L; LOIRE R; PERINETTI M; HONNORAT J; RICHE G; BARTHELET M; NINET J; CHAZOT G; CHASSIGNOLLE J; TROUILLAS P;
Indirizzi:
HOP NEUROL,SERV NEUROL PR P TROUILLAS URGENCES NEUROVASC,50 BD PINEL F-69003 LYON FRANCE PIERRE WERTHEIMER HOSP,DEPT NEUROL C LYON FRANCE PIERRE WERTHEIMER HOSP,DEPT NEUROL,CEREBROVASC DIS & ATAXIA RES CTR LYON FRANCE LOUIS PRADEL HOSP,ECHOCARDIOG LAB LYON FRANCE LOUIS PRADEL HOSP,DEPT PATHOL ANAT LYON FRANCE LOUIS PRADEL HOSP,DEPT CARDIAC SURG C LYON FRANCE LOUIS PRADEL HOSP,DEPT CARDIAC SURG A LYON FRANCE
Titolo Testata:
Archives of neurology
fascicolo: 1, volume: 54, anno: 1997,
pagine: 41 - 44
SICI:
0003-9942(1997)54:1<41:GLE-AU>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARDIAC PAPILLARY FIBROELASTOMA; TRANSESOPHAGEAL ECHOCARDIOGRAPHY; SYSTEMIC EMBOLIZATION; STROKE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
N. Nighoghossian et al., "GIANT LAMBL EXCRESCENCES - AN UNUSUAL SOURCE OF CEREBRAL EMBOLISM", Archives of neurology, 54(1), 1997, pp. 41-44

Abstract

Background: A possible association of giant Lambl excrescences (LEs) with stroke has been suggested. However, the treatment of giant LEs iscontroversial because minimal data are available. Objective: To clarify the management of giant LEs through a clinicopathologic study. CaseSeries: Three young patients (2 women and 1 man) who experienced ischemic stroke were studied. Results of general examinations were normal,as were chest xray films, electrocardiograms, ultrasonograms of the neck, and cerebral angiograms. Extensive serological and blood testing failed to show any coagulopathies or systemic disorders that favored astroke in these patients. Transesophageal echocardiography showed a mitral valve lesion (width, >1 mm). Two patients (cases 1 and 3) were discharged on a regimen of anticoagulant therapy and sequential transesophageal echocardiographic monitoring was planned, whereas 1 patient (case 2) was promptly scheduled for surgery. A second stroke occurred in patients 1 and 3 at 3 and 6 months, respectively, thus leading to surgery in these 2 patients. Findings from histopathologic studies were consistent with the diagnosis of giant LEs. The patients' outcomes were uneventful after surgery, and none had a recurrence of a stroke. Conclusions: A relationship between giant LEs and stroke may be suggested. In patients who have transesophageal echocardiographic findings thatare consistent with this diagnosis and recurrent stroke despite antithrombotic therapy and without an alternative explanation for the ischemic symptoms, surgery should be considered in view of these findings.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 15:52:04