Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
INFLUENCE OF SMOKING-BEHAVIOR IN RELATION TO PLASMA RETINOL AND ALPHA-TOCOPHEROL ON SISTER-CHROMATID EXCHANGES IN HUMAN PERIPHERAL-BLOOD LYMPHOCYTES
Autore:
HAGEMAN G; VANDENOETELAAR A; WELLE I; BEURSKENSCOMUTH P; KLEINJANS J;
Indirizzi:
UNIV LIMBURG,DEPT HLTH RISK ANAL & TOXICOL,POB 616 6200 MD MAASTRICHTNETHERLANDS
Titolo Testata:
Cancer epidemiology, biomarkers & prevention
fascicolo: 3, volume: 4, anno: 1995,
pagine: 289 - 293
SICI:
1055-9965(1995)4:3<289:IOSIRT>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
COAL FLY-ASH; CIGARETTE-SMOKE; BETA-CAROTENE; HYDROGEN-PEROXIDE; GENOTOXIC RISK; VITAMIN-A; FREQUENCY; ANTIOXIDANTS; POPULATION; EXPOSURE;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
G. Hageman et al., "INFLUENCE OF SMOKING-BEHAVIOR IN RELATION TO PLASMA RETINOL AND ALPHA-TOCOPHEROL ON SISTER-CHROMATID EXCHANGES IN HUMAN PERIPHERAL-BLOOD LYMPHOCYTES", Cancer epidemiology, biomarkers & prevention, 4(3), 1995, pp. 289-293

Abstract

The present study was undertaken to evaluate the contribution of various individual characteristics and lifestyle factors on sister chromatid exchange (SCE) frequencies in human peripheral blood lymphocytes (PBLs). These also included associations between plasma retinol and cu-tocopherol and SCE frequencies. The study population consisted of 50 healthy, smoking and nonsmoking, male and female volunteers, ages 22-49. SCE frequencies in PBLs were significantly higher in smokers than in nonsmokers. SCE frequencies correlated with variables of smoking habits and history, with the number of pack-years smoked correlating most strongly (r = 0.501; P < 0.001). Inverse but nonsignificant correlations were observed between plasma retinol and a-tocopherol levels and SCEfrequencies in PBLs. In addition, with the use of multiple regressionanalysis, significant associations were found with age and possible occupational exposure after adjustment for smoking habits (r(2) = 0.428; P = 0.0001). For males (n = 20), SCE frequencies were found to be associated significantly with the number of cigarettes smoked per day and possible occupational exposure (r(2) = 0.485; P < 0.01). SCE frequencies in PBLs of females (n = 30) were associated positively with the number of pack-years smoked and age, and significantly inversely correlated with plasma alpha-tocopherol concentrations (r(2) = 0.586; P = 0.0001). After exclusion of possible occupationally exposed persons (n =8) from the study population and adjustment for the effects of age and smoking behavior, a weak inverse correlation was found between plasma alpha-tocopherol and SCE frequencies (r = -0.286; P = 0.0732). Results of this study suggest that a-tocopherol may exert a reducing effecton tobacco smoke-induced DNA damage such as SCE frequencies. it is concluded that a careful control for the effects of possible confoundinglifestyle factors is warranted in studies evaluating the genetic effects of occupational or environmental exposure to genotoxic agents.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/10/20 alle ore 09:30:59