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Titolo:
EFFECT OF LOADING RIGHT ATRIAL AND VENTRICULAR RECEPTORS ON STIMULATED AVP, ACTH, AND RENIN SECRETION IN AWAKE DOGS
Autore:
ANDERSEN LJ; ANDERSEN JL; THRASHER TN; KEIL LC; RAMSAY DJ;
Indirizzi:
UNIV CALIF SAN FRANCISCO,SCH MED,DEPT PHYSIOL,BOX 0444 SAN FRANCISCO CA 94143 UNIV CALIF SAN FRANCISCO,SCH MED,DEPT PHYSIOL SAN FRANCISCO CA 94143 NASA,AMES RES CTR MOFFETT FIELD CA 94035
Titolo Testata:
American journal of physiology. Regulatory, integrative and comparative physiology
fascicolo: 4, volume: 37, anno: 1995,
pagine: 1069 - 1077
SICI:
0363-6119(1995)37:4<1069:EOLRAA>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONSCIOUS DOGS; NATRIURETIC PEPTIDES; ARTERIAL-HYPOTENSION; PLASMA VASOPRESSIN; PRESSURE; STRETCH; RELEASE; RADIOIMMUNOASSAY; INHIBITION; MECHANISM;
Keywords:
BLOOD PRESSURE; CARDIAC RECEPTORS; ARTERIAL BARORECEPTORS; ANTIDIURETIC HORMONE; CORTISOL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
L.J. Andersen et al., "EFFECT OF LOADING RIGHT ATRIAL AND VENTRICULAR RECEPTORS ON STIMULATED AVP, ACTH, AND RENIN SECRETION IN AWAKE DOGS", American journal of physiology. Regulatory, integrative and comparative physiology, 37(4), 1995, pp. 1069-1077

Abstract

The goal of this study was to test the hypothesis that increasing or decreasing the load on baroreceptors in the right heart influenced thesecretion of arginine vasopressin (AVP), adrenocorticotropic hormone (ACTH), and renin during a state of sustained arterial hypotension. The hypothesis was tested in chronically instrumented conscious dogs prepared with inflatable cuffs around the pulmonary artery (PA) and the thoracic inferior vena cava (IVC). In one protocol (n = 5), mean arterial pressure was reduced 10 or 20% below control by constriction of thePA, a maneuver that caused a fall in left atrial pressure (LAP) and an increase in right atrial pressure (RAP). Plasma AVP, ACTH, atrial natriuretic peptide (ANP), and plasma renin activity (PRA) all increased(P < 0.05) in response to constriction of the PA. Reducing RAP to control by constriction of the IVC during maintained constriction of the PA had no effect on MAP, LAP, plasma AVP, ACTH, or PRA, but plasma ANPfell significantly. In a separate protocol (n = 4), constriction of the IVC was used to reduce MAP 10 or 20% below control, and this led tosignificant decreases in both LAP and RAP and increases in plasma AVP, ACTH, and PRA. RAP was then increased above control by constriction of the PA without altering either MAP or LAP. Raising RAP from a levelthat was 6.3 +/- 1.3 mmHg below control to 3.5 +/- 1.0 mmHg above control had no effect on plasma AVP, ACTH, or PRA. These results show that, against constant reductions in MAP and LAP, acute changes in RAP over a 9-mmHg range have no effect on plasma AVP, ACTH, or PRA. Therefore, in contrast to the potent inhibitory effect of loading left atrial receptors on secretion of AVP, ACTH, and renin, we conclude that baroreceptors on the right. side of the heart have minimal influence on thesecretion of AVP, ACTH, and renin in conscious dogs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 11:22:19