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Titolo:
DIFFERENTIAL-EFFECTS OF WAY-100135 ON THE DECREASE IN 5-HYDROXYTRYPTAMINE RELEASE INDUCED BY BUSPIRONE AND NAN-190
Autore:
ROUTLEDGE C; GURLING J; ASHWORTHPREECE MA; DOURISH CT;
Indirizzi:
SMITHKLINE BEECHAM,NEW FRONTIERS SCI PK N,3RD AVE HARLOW CM19 5AD ESSEX ENGLAND WYETH RES UK,DEPT NEUROPHARMACOL MAIDENHEAD SL6 0PH BERKS ENGLAND
Titolo Testata:
European journal of pharmacology
fascicolo: 3, volume: 276, anno: 1995,
pagine: 281 - 284
SICI:
0014-2999(1995)276:3<281:DOWOTD>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSTSYNAPTIC 5-HT(1A) RECEPTORS; SELECTIVE ANTAGONIST; BRAIN MICRODIALYSIS; IN-VIVO; AGONISTS; WAY100135; INVIVO;
Keywords:
5-HT1A RECEPTOR ANTAGONIST; WAY-100135; NAN-190; MICRODIALYSIS;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
C. Routledge et al., "DIFFERENTIAL-EFFECTS OF WAY-100135 ON THE DECREASE IN 5-HYDROXYTRYPTAMINE RELEASE INDUCED BY BUSPIRONE AND NAN-190", European journal of pharmacology, 276(3), 1995, pp. 281-284

Abstract

1-(2-Methoxyphenyl)-3-[(phthalimido)butyl] piperazine (NAN-190) and 8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-8- azaspiro[4.5]decane-7,9-dione (buspirone) are 5-HT1A receptor partial agonists which decrease5-hydrolrytryptamine (5-HT) release in vivo. In order to assess whether these ligands decrease 5-HT release by stimulating 5-HT1A receptorswe examined the ability of the selective 5-HT1A receptor antagonist N-tert-butyl 3-4-(2-methoxyphenyl) piperazin-1-yl-2-phenylpropanamide dihydrochloride (WAY-100135) to block their inhibitory effects on 5-HT. NAN-190 (0.1 mg/kg s.c.) and buspirone (1.0 mg/kg s.c.) significantlydecreased extracellular levels of 5-HT in hippocampal dialysates. WAY-100135 (10.0 mg/kg s.c.) attenuated the effect of buspirone but had no significant effect on the NAN-190-induced decrease in 5-HT release. These data demonstrate that buspirone is an agonist at the somatodendritic 5-HT1A receptor but that the inhibitory effects of NAN-190 on 5-HT release may be mediated via a mechanism other than, or in addition to, 5-HT1A receptor agonism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 07:26:31