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Titolo:
EFFECT OF ZINC ON THE ANTIINFLAMMATORY AND ULCEROGENIC ACTIVITIES OF INDOMETHACIN AND DICLOFENAC
Autore:
ABOUMOHAMED G; ELKASHEF H; SALEM HA; ELMAZAR MM;
Indirizzi:
MED COLL GEORGIA,DEPT PHARMACOL & TOXICOL AUGUSTA GA 30912 MANSOURA UNIV,FAC PHARM,DEPT BIOCHEM & PHARMACOL MANSOURA EGYPT
Titolo Testata:
Pharmacology
fascicolo: 4, volume: 50, anno: 1995,
pagine: 266 - 272
SICI:
0031-7012(1995)50:4<266:EOZOTA>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
GASTRIC-MUCOSAL DAMAGE; SODIUM; ACID; RATS; COPPER; PROSTAGLANDIN-E2; INDOMETHACIN; REAPPRAISAL; METABOLISM; ACEXAMATE;
Keywords:
ZINC; ANTIINFLAMMATORY; ULCER, RATS; INFLAMMATION; INDOMETHACIN; DICLOFENAC;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
G. Aboumohamed et al., "EFFECT OF ZINC ON THE ANTIINFLAMMATORY AND ULCEROGENIC ACTIVITIES OF INDOMETHACIN AND DICLOFENAC", Pharmacology, 50(4), 1995, pp. 266-272

Abstract

In the present study, the potential anti-inflammatory activity of zinc sulfate (zinc) has been examined in rats with acute and chronic inflammation. Additionally, we studied the effect of the concurrent administration of zinc on the anti-inflammatory activity of indometacin and diclofenac and their gastric side effects. Oral or subcutaneous administration of zinc (25 and 15 mg/kg, respectively) significantly reducedcarrageenan-induced paw edema, Subcutaneous co-administration of zinc(15 mg/kg) and indometacin (5 mg/kg) or diclofenac (10 mg/kg) resulted in a further reduction in paw edema which was more than either that produced by either agent alone. However, after oral co-administration of zinc and diclofenac the reduction in paw edema was not significantly different from that produced by either zinc or diclofenac alone. In rats with chronic inflammation, the administration of zinc (5 mg/kg s.c. for 7 days) proved as effective as either indometacin (3 mg/kg) or diclofenac (5 mg/kg), Co-administration of zinc with indometacin or diclofenac did not affect the level of activity of either drug. Co-administration of zinc did not affect the ulcerogenic effect of indometacinexpressed as the ulcer index. In contrast to indometacin, administration of zinc markedly reduced the ulcerative action of diclofenac. In conclusion, zinc supplementation may contribute significantly to the treatment of inflammation. The combination of zinc with other antiinflammatory drugs may provide beneficial additive effects and reduce their gastric hazards, particularly with diclofenac.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 05:36:26