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Titolo:
DIFFERENT PHARMACOLOGICAL ACTIONS OF ADENOSINE ON GASTRIC FUNCTION AND MUCOSAL DAMAGE IN NORMOTENSIVE AND SPONTANEOUSLY HYPERTENSIVE RATS
Autore:
CHO CH; KAAN SK; WANG HH;
Indirizzi:
UNIV HONG KONG,FAC MED,DEPT PHARMACOL HONG KONG HONG KONG
Titolo Testata:
Pharmacology
fascicolo: 4, volume: 50, anno: 1995,
pagine: 261 - 265
SICI:
0031-7012(1995)50:4<261:DPAOAO>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-PRESSURE; ACID SECRETION; ULCERATION;
Keywords:
ADENOSINE; GASTRIC SECRETORY FUNCTION; GASTRIC MUCOSAL BLOOD FLOW; ETHANOL; SPONTANEOUSLY HYPERTENSIVE RATS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
C.H. Cho et al., "DIFFERENT PHARMACOLOGICAL ACTIONS OF ADENOSINE ON GASTRIC FUNCTION AND MUCOSAL DAMAGE IN NORMOTENSIVE AND SPONTANEOUSLY HYPERTENSIVE RATS", Pharmacology, 50(4), 1995, pp. 261-265

Abstract

It has been reported that there are functional defects in the purinergic system in spontaneously hypertensive rats (SHR). The following experiments examined the gastric effects of adenosine in these animals. SHR had a significantly higher gastric mucosal blood flow (GMBF), but the secretion of acid and pepsin was not different from that of normotensive counterparts. In SHR, adenosine (s.c. 3.75 or 7.5 mg/kg) time and dose-dependently decreased gastric acid secretion and GMBF. The nucleoside, however, did not affect the pepsin secretion. In normotensive rats, gastric acid secretion was also reduced, but not to the extent of SHR. The GMBF was increased instead. Adenosine potentiated ethanol-induced mucosal damage in SHR, which was likely caused by GMBF reduction. It is concluded that adenosine produces a greater depressive actionon the stomach in SHR. These differential actions are probably due tothe genetic difference between the two types of animals.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 10:25:35