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Titolo:
KINETICS AND UPTAKE IN-VIVO OF OXIDATIVELY MODIFIED LYMPH CHYLOMICRONS
Autore:
UMEDA Y; REDGRAVE TG; MORTIMER BC; MAMO JCL;
Indirizzi:
UNIV WESTERN AUSTRALIA,DEPT PHYSIOL,STIRLING HWY NEDLANDS WA 6009 AUSTRALIA UNIV WESTERN AUSTRALIA,DEPT PHYSIOL NEDLANDS WA 6009 AUSTRALIA
Titolo Testata:
American journal of physiology: Gastrointestinal and liver physiology
fascicolo: 4, volume: 31, anno: 1995,
pagine: 709 - 716
SICI:
0193-1857(1995)31:4<709:KAUIOO>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; HUMAN MONOCYTE-MACROPHAGES; RAT-LIVER; REMNANT CLEARANCE; KUPFFER CELLS; BONE-MARROW; RECEPTOR; INVIVO; DEGRADATION; METABOLISM;
Keywords:
LIPIDS; OXIDATION; LIPOPROTEINS; LIVER; RETICULOENDOTHELIAL; ATHEROSCLEROSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
Y. Umeda et al., "KINETICS AND UPTAKE IN-VIVO OF OXIDATIVELY MODIFIED LYMPH CHYLOMICRONS", American journal of physiology: Gastrointestinal and liver physiology, 31(4), 1995, pp. 709-716

Abstract

The metabolism of oxidized chylomicrons (ox-CMs) was investigated in vivo. CMs from rats fed corn, linseed, or fish oil were oxidized by incubation with 2,2'-azobis(2-amidinopropane)hydrochloride (AAPH) or sodium hypochlorite (NaOCl). Oxidized CMs had a rapid phase of clearance,followed by a slow phase. Clearance of ox-CMs was decreased for corn oil but increased for linseed and fish oil particles. Differences in rates of uptake between CM types or treatment were independent of the rate of remnant formation, but were instead a consequence of decreased clearance. A greater triglyceride-to-cholesteryl ester ratio in liver suggested that there was less lipolysis of ox-CM triglyceride prior touptake. Hepatic uptake of ox-CMs was decreased, whereas there was increased uptake in spleen. However, the uptake by Kupffer cells of ox-CMs was 43% of total liver uptake after AAPH treatment and 59% after NaOCl treatment, compared with 21% for control CMs. Collectively, our data show that oxidation can have differential effects on the rate of clearance of CMs and that ox-CMs are preferentially cleared by the reticuloendothelial system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/02/20 alle ore 22:31:06