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Titolo:
EFFECTS OF AGING ON 24-H DYNAMIC BARORECEPTOR CONTROL OF HEART-RATE IN AMBULANT SUBJECTS
Autore:
PARATI G; FRATTOLA A; DIRIENZO M; CASTIGLIONI P; PEDOTTI A; MANCIA G;
Indirizzi:
CTR FISIOL CLIN & IPERTENS,VIA F SFORZA 35 I-20122 MILAN ITALY UNIV MILAN I-20122 MILAN ITALY OSPED SAN GERARDO I-20122 MILAN ITALY IST SCI OSPED S LUCA,CTR AUXOL ITALIANO I-20149 MILAN ITALY FDN JUVENTUTE,CTR BIOINGN,RIC CARDIOVASC LAB I-20148 MILAN ITALY
Titolo Testata:
American journal of physiology. Heart and circulatory physiology
fascicolo: 4, volume: 37, anno: 1995,
pagine: 1606 - 1612
SICI:
0363-6135(1995)37:4<1606:EOAO2D>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
ARTERIAL BLOOD-PRESSURE; SEQUENTIAL SPECTRAL-ANALYSIS; BAROREFLEX SENSITIVITY; RATE VARIABILITIES; PULSE INTERVAL; RATE REFLEX; HUMANS; HYPERTENSION; AGE;
Keywords:
SPECTRAL ANALYSIS; BLOOD PRESSURE VARIABILITY; BAROREFLEXES; AMBULATORY BLOOD PRESSURE MONITORING; VARIABILITY; SEQUENCE ANALYSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
G. Parati et al., "EFFECTS OF AGING ON 24-H DYNAMIC BARORECEPTOR CONTROL OF HEART-RATE IN AMBULANT SUBJECTS", American journal of physiology. Heart and circulatory physiology, 37(4), 1995, pp. 1606-1612

Abstract

The effects of aging on the dynamic modulation of baroreflex sensitivity over 24 h was assessed in eight elderly (mean age +/- SD, 63.9 +/-3.2 yr) and in eight young (23.9 +/- 6.1 yr) mild or moderate essential hypertensive patients, who were subject to a 24-h intra-arterial (Oxford technique) blood pressure recording in ambulatory conditions. The sensitivity of baroreflex control of the heart rate was dynamically assessed by quantifying 1) the slope of the regression line between pulse interval (the reciprocal of heart rate) and systolic blood pressure changes over spontaneously occurring hypertension-bradycardia or hypotension-tachycardia sequences (time domain analysis) and 2) the ratiobetween spectral powers of pulse interval and systolic blood pressurearound 0.1 Hz (alpha-coefficient: frequency domain analysis). The 24-h average sequence slope was lower in old than in young individuals (4.4 +/- 0.5 vs. 9.9 +/- 1.3 and 4.8 +/- 0.7 vs. 8.4 +/- 1.4 ms/mmHg forhypertension-bradycardia and hypotension-tachycardia sequences, respectively; P < 0.05 for both). Similar results were obtained by using the alpha-coefficient approach. The marked nighttime increase in baroreflex sensitivity observed in young individuals was much less evident inthe elderly. Thus 24-h baroreflex sensitivity is markedly impaired byaging. The impairment becomes manifest also as an inability to increase baroreflex sensitivity at night.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 00:42:17