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Titolo:
PROTEOLYTIC-ENZYMES AS INDICATORS OF PERIODONTAL HEALTH IN GINGIVAL CREVICULAR FLUID OF PATIENTS WITH SJOGRENS-SYNDROME
Autore:
TERVAHARTIALA T; INGMAN T; SORSA T; DING YL; KANGASPUNTA P; KONTTINEN YT;
Indirizzi:
HELSINKI UNIV,INST DENT,DEPT ANAT,PB 41,MANNERHEIMINT 172 SF-00014 HELSINKI FINLAND HELSINKI UNIV,DEPT MED CHEM SF-00014 HELSINKI FINLAND HELSINKI UNIV,DEPT PERIODONTOL SF-00014 HELSINKI FINLAND
Titolo Testata:
European journal of oral sciences
fascicolo: 1, volume: 103, anno: 1995,
pagine: 11 - 16
SICI:
0909-8836(1995)103:1<11:PAIOPH>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN FIBROBLAST COLLAGENASE; POLYMORPHONUCLEAR LEUKOCYTES; MATRIX METALLOPROTEINASES; INTERSTITIAL COLLAGENASES; COLLAGENOLYTIC ACTIVITY; BACTEROIDES-GINGIVALIS; PARTIAL-PURIFICATION; TRYPSIN-LIKE; ACTIVATION; MECHANISMS;
Keywords:
GINGIVAL CREVICULAR FLUID; PERIODONTITIS; PROTEINASES; SJOGRENS SYNDROME;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
T. Tervahartiala et al., "PROTEOLYTIC-ENZYMES AS INDICATORS OF PERIODONTAL HEALTH IN GINGIVAL CREVICULAR FLUID OF PATIENTS WITH SJOGRENS-SYNDROME", European journal of oral sciences, 103(1), 1995, pp. 11-16

Abstract

The present study characterizes the periodontal status of patients with Sjogren's syndrome (SS) and measures collagenase, elastase and gelatinase in gingival crevicular fluid (GCF) from these patients comparedwith adult individuals with periodontitis and healthy controls. The periodontal status was assessed by the Gingival Bleeding Index (GBI), the Visible Plaque Index (VPI), and pocket depth. Activity measurementswere performed for collagenase with SDS-PAGE/laser densitometry, for elastase spectrophotometrically using a synthetic N-succinyl-Ala-Ala-Val p-nitroanilide peptide substrate, and for gelatinase with zymography. Seven of the 8 patients with SS and xerostomia showed a periodontium comparable to that seen in healthy controls. The GCF collagenase andelastase were significantly lower in patients with SS and in healthy controls than in patients with adult periodontitis. It was noteworthy that the one SS patient with periodontitis had high GCF collagenase and elastase activity. In all study groups multiple forms of gelatinaseswere present, indicating that they represent constitutively expressedproteinases involved in normal tissue remodeling processes. Our findings suggest that periodontal pockets/GCF form a micromilieu not affected by involvement of glandular tissue and, therefore, patients with SSshow, clinically and biochemically, a periodontal status comparable to that seen in healthy controls.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 20:25:39