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Titolo:
NERVE-DEPENDENT PLASTICITY OF THE GOLGI-COMPLEX IN SKELETAL-MUSCLE FIBERS - COMPARTMENTALIZATION WITHIN THE SUBNEURAL SARCOPLASM
Autore:
JASMIN BJ; ANTONY C; CHANGEUX JP; CARTAUD J;
Indirizzi:
UNIV PARIS 07,CNRS,INST JACQUES MONOD,DEPT BIOL SUPRAMOLEC & CELLULAIRE,2 PL JUSSIEU F-75251 PARIS 05 FRANCE UNIV PARIS 07,CNRS,INST JACQUES MONOD,DEPT BIOL SUPRAMOLEC & CELLULAIRE F-75251 PARIS 05 FRANCE UNIV OTTAWA,FAC MED,DEPT PHYSIOL OTTAWA ON K1H 8M5 CANADA INST PASTEUR,CNRS,DEPT BIOTECHNOL F-75724 PARIS 15 FRANCE
Titolo Testata:
European journal of neuroscience
fascicolo: 3, volume: 7, anno: 1995,
pagine: 470 - 479
SICI:
0953-816X(1995)7:3<470:NPOTGI>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
PREFERENTIAL SYNAPTIC EXPRESSION; MESSENGER-RNA ACCUMULATION; ALPHA-MANNOSIDASE-II; ACETYLCHOLINE-RECEPTOR; NEUROMUSCULAR-JUNCTION; APPARATUS; MEMBRANE; CHICK; MICROTUBULES; MYOGENESIS;
Keywords:
NEUROMUSCULAR JUNCTION; SECRETORY PATHWAY; COMPARTMENTALIZATION; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
52
Recensione:
Indirizzi per estratti:
Citazione:
B.J. Jasmin et al., "NERVE-DEPENDENT PLASTICITY OF THE GOLGI-COMPLEX IN SKELETAL-MUSCLE FIBERS - COMPARTMENTALIZATION WITHIN THE SUBNEURAL SARCOPLASM", European journal of neuroscience, 7(3), 1995, pp. 470-479

Abstract

Several recent reports have highlighted the plasticity of the Golgi apparatus during myogenesis, yet the organization of this specialized organelle in innervated skeletal muscle fibres remains poorly understood. Using four bona fide anti-Golgi antibodies, directed against a 210 kDa protein, a 160 kDa sialoglycoprotein, the small GTP-binding protein rab6p, and TGN38, the localization of which covers the various compartments of the Golgi complex, we show by immunofluorescence microscopythat the Golgi complex undergoes considerable reorganization in the course of myogenic differentiation and motor endplate formation in the rat, Unlike the typical perinuclear distribution of the Golgi stacks associated with every nucleus in myotubes, a striking subneural compartmentalization is observed in adult innervated myofibres. In short-termdenervated adult muscle fibres, we noticed the presence of the perinuclear Golgi apparatus in extrajunctional regions, a pattern reminiscent of that of developing myotubes, At variance with anti-Golgi antibodies, antibodies to the rough endoplasmic reticulum label structures dispersed throughout the entire sarcoplasm, hence suggesting that it is not the entire membrane/secretory protein synthesis machinery which is compartmentalized, but only the Golgi apparatus. Also, an unexpected lack of immunoreactivity with the TGN38 and a-mannosidase II antibodiespoints to biochemical differentiation of the subneural Golgi apparatus at the adult motor endplate. These new data extend our previous observations on the compartmentalization of the Golgi apparatus in the postsynaptic sarcoplasm of chick muscle fibres, and further illustrate the plasticity of the Golgi apparatus in muscle cells, The specialization of the Golgi apparatus within the subneural compartment provides this particular region with a compartmentalized secretory pathway, and these observations highlight the notion that the level of differentiation of this domain is not only maintained via transcriptional regulationbut also by post-translational control mechanisms.

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Documento generato il 24/11/20 alle ore 13:04:56