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Titolo:
SEQUENTIAL GONADOTROPIN-RELEASING-HORMONE AGONIST LOW-DOSE ORAL-CONTRACEPTIVE TREATMENT FOR LEIOMYOMATA UTERI
Autore:
BALASCH J; MANAU D; MIMO J; DURAN M; PUERTO B; VANRELL JA;
Indirizzi:
UNIV BARCELONA,HOSP CLIN & PROV,FAC MED,DEPT OBSTET & GYNAECOL,C CASANOVA 143 E-08036 BARCELONA SPAIN
Titolo Testata:
Human reproduction
fascicolo: 3, volume: 10, anno: 1995,
pagine: 529 - 532
SICI:
0268-1161(1995)10:3<529:SGALO>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
UNITED-STATES; FIBROIDS; WOMEN; HYSTERECTOMY; PREDICTORS; MYOMETRIUM; RECEPTORS; THERAPY; ACETATE; RISK;
Keywords:
GNRHA; LEIOMYOMA; MEDICAL THERAPY; ORAL CONTRACEPTIVES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
J. Balasch et al., "SEQUENTIAL GONADOTROPIN-RELEASING-HORMONE AGONIST LOW-DOSE ORAL-CONTRACEPTIVE TREATMENT FOR LEIOMYOMATA UTERI", Human reproduction, 10(3), 1995, pp. 529-532

Abstract

On the basis that gonadotrophin-releasing hormone agonists (GnRHa) induce a significant but transient shrinkage of leiomyomas and that oralcontraceptive use may be associated with a decreased risk of fibroids, we tested the hypothesis that sequential GnRHa/low-dose oral contraceptive treatment could be a therapeutic alternative in perimenopausal women with uterine fibroids, Six premenopausal women with leiomyomata uteri were treated with D-tryptophan-6-luteinizing hormone-releasing hormone (D-Trp-6-LHRH) depot (Decapeptyl 3.75) for 6 months and demonstrated a significant reduction in mean uterine volume, A low-dose oral contraceptive containing 30 mu g of ethinyl oestradiol plus 150 mu g of desogestrel was given during the ensuing 12 months, When GnRHa therapy was discontinued, there was a rapid regrowth of the uterine fibroids and the uterine volume had reached, or even exceeded, pretreatment values by the eighth to 12th month of contraceptive therapy, SequentialGnRHa/low-dose oral contraceptive treatment is not a useful tool for leiomyomata uteri.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 12:54:00