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Titolo:
MOUSEPOX OUTBREAK IN A LABORATORY MOUSE COLONY
Autore:
DICK EJ; KITTELL CL; MEYER H; FARRAR PL; ROPP SL; ESPOSITO JJ; BULLER RML; NEUBAUER H; KANG YH; MCKEE AE;
Indirizzi:
USA,MED RES INST CHEM DEF,CDR,MCMR,UV,CC,3100 RICKETTS POINT RD ABERDEEN PROVING GROUND MD 21010 USN,MED RES INST,TECH SERV DEPT BETHESDA MD 00000 FED ARMED FORCES MED ACAD,INST MICROBIOL MUNICH GERMANY ST LOUIS UNIV,HLTH SCI CTR,SCH MED,DEPT MOL MICROBIOL & IMMUNOL ST LOUIS MO 63103 ST LOUIS UNIV,HLTH SCI CTR,SCH MED,DEPT COMPARAT MED ST LOUIS MO 63103 CTR DIS CONTROL & PREVENT,NATL CTR INFECT DIS,DIV VIRAL & RICKETTSIALDIS ATLANTA GA 00000
Titolo Testata:
Laboratory animal science
fascicolo: 6, volume: 46, anno: 1996,
pagine: 602 - 611
SICI:
0023-6764(1996)46:6<602:MOIALM>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
MICE INNATELY RESISTANT; ECTROMELIA VIRUS; INBRED MICE; LETHAL INFECTION; INCLUSION-BODY; COWPOX VIRUS; PROTEIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
E.J. Dick et al., "MOUSEPOX OUTBREAK IN A LABORATORY MOUSE COLONY", Laboratory animal science, 46(6), 1996, pp. 602-611

Abstract

Mousepox was diagnosed in and eradicated from a laboratory mouse colony at the Naval Medical Research Institute. The outbreak began with increased mortality in a single room; subsequently, small numbers of animals in separate cages in other rooms were involved. Signs of disease were often mild, and overall mortality was low; BALB/cByJ mice were more severely affected, and many of them died spontaneously. Conjunctivitis was the most common clinical sign of disease in addition to occasional small, crusty scabs on sparsely haired or hairless areas of skin. Necropsy findings included conjunctivitis, enlarged spleen, and pale liver. Hemorrhage into the pyloric region of the stomach and proximal portion of the small. intestine was observed in experimentally infected animals. In immune competent and immune deficient mice, the most common histologic finding was multifocal to coalescing splenic necrosis; necrosis was seen less frequently in liver, lymph nodes, and Peyer's patches. Necrosis was rarely observed in ovary, vagina, uterus, colon, or lung. Splenic necrosis often involved over 50% of the examined tissue, including white and red pulp. Hepatic necrosis was evident as either large, well-demarcated areas of coagulative necrosis or as multiple, random, interlacing bands of necrosis. Intracytoplasmic eosinophilicinclusion bodies were seen in conjunctival mucosae and haired palpebra. Ectromelia virus was confirmed as the causative agent of the epizootic by electron microscopy, immunohistochemistry, animal inoculations,serologic testing, virus isolation, and polymerase chain reaction. Serologic testing was of little value in the initial stages of the outbreak, although 6 weeks later, orthopoxvirus-specific antibody was detected in colony mice by indirect fluorescent antibody and enzyme-linked immunosorbent assay procedures. The outbreak originated from injectionof mice with a contaminated, commercially produced, pooled mouse serum. The most relevant concern may be the unknown location of the sourceof the virus and the presence of a reservoir for this virus within the United States.

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Documento generato il 30/11/20 alle ore 09:49:49