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Titolo:
TRANSIENT EXPRESSION OF LOW-AFFINITY NGF RECEPTOR IN HUMAN DEVELOPINGSOMATOSENSORY PATHWAYS
Autore:
LIBERINI P; MEMO M; MORETTO G; PAROLINI S; SPANO PF;
Indirizzi:
UNIV BRESCIA,SCH MED,DEPT BIOMED SCI & TECHNOL,PHARMACOL SECT,VIA VALSABBINA 19 I-25123 BRESCIA ITALY UNIV BRESCIA,SCH MED,DEPT BIOMED SCI & TECHNOL,HISTOL SECT I-25123 BRESCIA ITALY UNIV VERONA,SCH MED,DEPT NEUROL & VISUAL SCI,NEUROL SECT I-37100 VERONA ITALY
Titolo Testata:
Neuroscience research communications
fascicolo: 2, volume: 16, anno: 1995,
pagine: 75 - 82
SICI:
0893-6609(1995)16:2<75:TEOLNR>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVE GROWTH-FACTOR; HUMAN SPINAL-CORD; IMMUNOREACTIVITY; GANGLIA; NEURONS; FAMILY; BRAIN;
Keywords:
DEVELOPMENT; HUMAN; IMMUNOHISTOCHEMISTRY; P75 NERVE GROWTH FACTOR RECEPTOR; SPINAL CORD; SOMATOSENSORY PATHWAYS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
P. Liberini et al., "TRANSIENT EXPRESSION OF LOW-AFFINITY NGF RECEPTOR IN HUMAN DEVELOPINGSOMATOSENSORY PATHWAYS", Neuroscience research communications, 16(2), 1995, pp. 75-82

Abstract

A monoclonal antibody recognizing the low affinity receptor for nervegrowth factor (p75(NGFR)) has been used to determine and compare the immunohistochemical expression of p75(NGFR) in foetal (8 to 25 weeks of gestation) and adult human spinal cord. This comparison was carried out with the aim to get a better insight on neurotrophin functions during spinal cord development. In developing spinal cords an intense p75(NGFR) fiber immunoreactivity was observed in the dorsal root, the dorsal and dorsolateral funiculi, and in restricted regions of the dorsalhorn. A plexus of p75(NGFR) immunostaining was found in the ventral horn. In adult spinal cord, strong fiber immunoreactivity was localizedin the dorsal root, in the superficial layers of the dorsal horn (lamina I and II) but not in dorsal and dorsolateral funiculi. Immunoreactive neurons were detected in the ventral horn (lamina IX). The transient, selective pattern of p75(NGFR) in the dorsal and dorsolateral funiculi may indicate an involvement of neurotrophins in the modulation oftactile and kinaesthetic information during foetal life.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 02:09:01