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Titolo:
STAGE SENSITIVITY OF PLASMODIUM-VINCKEI-PETTERI TO QUININE, MEFLOQUINE, AND PYRIMETHAMINE
Autore:
CAILLARD V; BEAUTELAFITTE A; CHABAUD A; GINSBURG H; LANDAU I;
Indirizzi:
MUSEUM NATL HIST NAT,BIOL PARASITAIRE & CHIMIOTHERAPIE LAB,CNRS,URA 114,61 RUE BUFFON F-75005 PARIS FRANCE MUSEUM NATL HIST NAT,EPHE,PROTOZOOL & PARASITOL COMPAREE LAB F-75005 PARIS FRANCE
Titolo Testata:
The Journal of parasitology
fascicolo: 2, volume: 81, anno: 1995,
pagine: 295 - 301
SICI:
0022-3395(1995)81:2<295:SSOPTQ>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
FALCIPARUM-MALARIA; RODENT MALARIA; CLINICAL PHARMACOKINETICS; SULFADOXINE; CHEMOTHERAPY; PARASITES; DRUGS; IDENTIFICATION; CHRONOTHERAPY; PHAGOCYTOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
V. Caillard et al., "STAGE SENSITIVITY OF PLASMODIUM-VINCKEI-PETTERI TO QUININE, MEFLOQUINE, AND PYRIMETHAMINE", The Journal of parasitology, 81(2), 1995, pp. 295-301

Abstract

The stage-dependent sensitivity of Plasmodium vinckei petteri to the antimalarial drugs quinine, mefloquine, and pyrimethamine was investigated using single subcurative doses and 2 different tests: a prepatency test evidencing the extension of the prepatent period according to the stage at which the drug was administered, and a patency test showing the morphological alterations of the parasites and the modificationsof the parasitic pattern following drug treatment. Quinine activity was maximal when it hit the midterm trophozoite. No pigment clumping was seen and parasites developed normally until they reached the schizogonic stage when they became morphologically altered and unproductive. Mefloquine also acted on the midterm trophozoites. Parasites at this stage were killed immediately by the drug as evidenced by their degenerative appearance, and dead parasites lingered in the blood smears for at least 6 hr. However, although mefloquine was active during at least48 hr (2 cycles), some trophozoites escaped destruction. The schizontstage was found to be the most sensitive to pyrimethamine, as previously reported for other parasite species. These results add to our previous reports showing that each drug acts preferentially on a specific stage of parasite development.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/11/20 alle ore 20:28:33