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Titolo:
CLONIDINE - AN ADJUNCT IN ISOFLURANE N2O O-2 RELAXANT ANESTHESIA - EFFECTS ON EEG POWER SPECTRA, SOMATOSENSORY AND AUDITORY-EVOKED POTENTIALS/
Autore:
GABRIEL AH; FARYNIAK B; SOJKA G; CZECH T; FREYE E; SPISS CK;
Indirizzi:
UNIV VIENNA,DEPT ANESTHESIA & GEN INTENS CARE,NEUROANESTHESIA RES GRPVIENNA AUSTRIA UNIV VIENNA,DEPT NEUROSURG VIENNA AUSTRIA UNIV DUSSELDORF,DEPT VASC SURG & RENAL TRANSPLANTAT DUSSELDORF GERMANY
Titolo Testata:
Anaesthesia
fascicolo: 4, volume: 50, anno: 1995,
pagine: 290 - 296
SICI:
0003-2409(1995)50:4<290:C-AAII>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOOP FEEDBACK-CONTROL; PERIOPERATIVE HEMODYNAMICS; NOCICEPTIVE NEUROTRANSMISSION; ALPHA-2-ADRENOCEPTOR AGONIST; ANESTHETIC REQUIREMENT; INTRAVENOUS CLONIDINE; FENTANYL ANESTHESIA; NITROUS-OXIDE; SURGERY; DEXMEDETOMIDINE;
Keywords:
SYMPATHETIC NERVOUS SYSTEM, PHARMACOLOGY, CLONIDINE; BRAIN, EVOKED POTENTIALS, AUDITORY, SOMATOSENSORY, EEG;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
A.H. Gabriel et al., "CLONIDINE - AN ADJUNCT IN ISOFLURANE N2O O-2 RELAXANT ANESTHESIA - EFFECTS ON EEG POWER SPECTRA, SOMATOSENSORY AND AUDITORY-EVOKED POTENTIALS/", Anaesthesia, 50(4), 1995, pp. 290-296

Abstract

We investigated the effect of clonidine in 19 patients having lumbar disc surgery under nitrous oxide/isoflurane/relaxant anaesthesia. The EEG, spinal and cortical somatosensory evoked potentials, and the brainstem auditory evoked potentials were recorded. After equilibration ofthe general anaesthetic, two successive infusions of clonidine (5 mu g.kg(-1)) were given. After the second infusion of clonidine, the plasma concentration increased from 0.2(SEM 0.05) to 6.4(SEM 0.06)ng.ml(-1) (p < 0.05). In the EEG, delta-activity was maintained, but the beta-fraction, and the 95% and 50% spectral frequencies were reduced. TotalEEG power progressively decreased from 296(152-397)mu V-2 to 108(51-240)mu V-2. The somatosensory evoked spinal potential (N13) decreased in amplitude, (1.77(SEM 0.35)mu V to 1.59(SEM 0.35)mu V, p < 0.05) and increased in latency (14.37(SEM 0.29)ms to 14.69(SEM 0.31)ms, p < 0.05). The central conduction time increased from 6.47(SEM 0.16)ms to 6.92(SEM 0.25)ms, ns. There was no effect on the cortical somatosensory potentials, or the brainstem auditory evoked potentials. According to the EEG spectral indices, anaesthesia appealed to deepen despite a reduction in the end expiratory isoflurane concentration from 0.53(SEM 0.07) to 0.28(SEM 0.06)vol%, which indicated a reduction in anaesthetic requirements following clonidine.

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Documento generato il 04/07/20 alle ore 23:17:20