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Titolo:
MULTIPLE MESSENGER-RNA ISOFORMS OF THE HUMAN RET PROTOONCOGENE GENERATED BY ALTERNATE SPLICING
Autore:
LORENZO MJ; ENG C; MULLIGAN LM; STONEHOUSE TJ; HEALEY CS; PONDER BAJ; SMITH DP;
Indirizzi:
UNIV CAMBRIDGE,DEPT PATHOL,CRC,HUMAN CANC GENET RES GRP,TENNIS COURT RD CAMBRIDGE CB2 1QP ENGLAND UNIV CAMBRIDGE,DEPT PATHOL,CRC,HUMAN CANC GENET RES GRP CAMBRIDGE CB21QP ENGLAND HARVARD UNIV,SCH MED,DEPT MED,DANA FARBER CANC INST,DIV MED ONCOL BOSTON MA 02115 HARVARD UNIV,SCH MED,DEPT MED,DANA FARBER CANC INST,DIV CANC EPIDEMIOL & CONTROL BOSTON MA 02115 QUEENS UNIV,DEPT PATHOL KINGSTON ON K7L 3N6 CANADA QUEENS UNIV,DEPT PAEDIAT KINGSTON ON K7L 3N6 CANADA
Titolo Testata:
Oncogene
fascicolo: 7, volume: 10, anno: 1995,
pagine: 1377 - 1383
SICI:
0950-9232(1995)10:7<1377:MMIOTH>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
TYROSINE KINASE; TRANSFORMING GENE; SOLUBLE RECEPTOR; II ONCOGENE; CELL-LINE; PROTOONCOGENE; SEQUENCE; CLONING; RNA; CARCINOMAS;
Keywords:
RET; RECEPTOR TYROSINE KINASE; ALTERNATE SPLICING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
M.J. Lorenzo et al., "MULTIPLE MESSENGER-RNA ISOFORMS OF THE HUMAN RET PROTOONCOGENE GENERATED BY ALTERNATE SPLICING", Oncogene, 10(7), 1995, pp. 1377-1383

Abstract

The RET proto-oncogene encodes a receptor tyrosine kinase. We and others have recently shown that distinct germline mutations of the BET proto-oncogene account for the majority of cases of the dominantly inherited multiple endocrine neoplasia (MEN) type 2 syndromes, and can cause a dominantly inherited form of Hirschsprung disease, a disorder of development of the autonomic innervation of the gut. RET is also oncogenically activated in some sporadic thyroid and adrenal tumours. Here we report the characterisation of multiple mRNA isoforms of RET generated by alternate splicing. Two isoforms are predicted to encode membrane-spanning receptors with a truncated extracellular ligand-binding domain. A third isoform is predicted to encode a soluble, secreted form of the receptor, These mRNA isoforms are expressed in both normal and tumour tissues.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 04:12:42