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Titolo:
DENTATE GYRUS FORMATION REQUIRES EMX2
Autore:
PELLEGRINI M; MANSOURI A; SIMEONE A; BONCINELLI E; GRUSS P;
Indirizzi:
MAX PLANCK INST BIOPHYS CHEM,FASSBERG D-37077 GOTTINGEN GERMANY CNR,INT INST GENET & BIOPHYS I-80125 NAPLES ITALY IST SCI HS RAFFAELE,DIBIT I-20132 MILAN ITALY DIPARTIMENTO SCI MORFOL & MED LEGALI,SEZ ISTOL EMBRIOL & GENET I-41100 MODENA ITALY CNR,CTR STUDIO FARMACOL CELLULARE & MOL I-20129 MILAN ITALY
Titolo Testata:
Development
fascicolo: 12, volume: 122, anno: 1996,
pagine: 3893 - 3898
SICI:
0950-1991(1996)122:12<3893:DGFRE>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESTRICTED EXPRESSION; HOMEOBOX GENES; GRANULE CELLS; REELER MICE; HIPPOCAMPUS; FOREBRAIN; BRAIN; ORGANIZATION; HOMEODOMAIN; MORPHOLOGY;
Keywords:
EMX2; DENTATE GYRUS; MEDIAL LIMBIC CORTEX; CEREBRAL HEMISPHERES; CEREBRAL CORTEX; TELENCEPHALON;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
M. Pellegrini et al., "DENTATE GYRUS FORMATION REQUIRES EMX2", Development, 122(12), 1996, pp. 3893-3898

Abstract

Emx 1 and 2 are the murine homologues of the Drosophila empty spiracles gene and based on their expression pattern may be involved in the regional specification of the mammalian forebrain. During early embryogenesis, Emx2 is expressed in the presumptive cerebral cortex and olfactory bulbs and later, in the hippocampus proper and dentate gyrus. Thelatter are involved in memory processes. To understand the role of Emx2 in vivo, we have mutated the gene in mice. Homozygous embryos die postnatally because of severe urogenital alterations. These mice present cerebral hemispheres with a reduced size and exhibit specific morphological alterations in allocortical structures of the medial wall of the brain. The dentate gyrus is missing and the hippocampus proper is reduced. The medial limbic cortex is also severely shortened. The development of the dentate gyrus is affected at the onset of its formation with defects in the neuroepithelium from which it originates. These findings demonstrate that Emx2 is required for the development of several forebrain structures.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 18:05:47