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Titolo:
DEVELOPMENT OF SMOOTH-MUSCLE HYPERTROPHY IS CLOSELY ASSOCIATED WITH INCREASED GENE-EXPRESSION OF INSULIN-LIKE GROWTH-FACTOR BINDING PROTEIN-2 AND PROTEIN-4
Autore:
CHEN Y; ARNER A; BORNFELDT KE; UVELIUS B; ARNQVIST HJ;
Indirizzi:
LINKOPING UNIV,FAC HLTH SCI,DEPT CELL BIOL S-58185 LINKOPING SWEDEN LINKOPING UNIV,FAC HLTH SCI,DEPT PHARMACOL S-58185 LINKOPING SWEDEN LINKOPING UNIV,FAC HLTH SCI,DEPT INTERNAL MED S-58185 LINKOPING SWEDEN LUND UNIV,DEPT PHYSIOL & BIOPHYS S-22362 LUND SWEDEN LUND UNIV,DEPT UROL S-22362 LUND SWEDEN
Titolo Testata:
Growth regulation
fascicolo: 1, volume: 5, anno: 1995,
pagine: 45 - 52
SICI:
0956-523X(1995)5:1<45:DOSHIC>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
FACTOR-I GENE; OUTLET OBSTRUCTION; URINARY-BLADDER; RAT; CELLS; SEQUENCE; CLONING; HYBRIDIZATION; SECRETION;
Keywords:
IGF-I; IGFBP-2; IGFBP-4; SMOOTH MUSCLE HYPERTROPHY; IGF-I RECEPTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
Y. Chen et al., "DEVELOPMENT OF SMOOTH-MUSCLE HYPERTROPHY IS CLOSELY ASSOCIATED WITH INCREASED GENE-EXPRESSION OF INSULIN-LIKE GROWTH-FACTOR BINDING PROTEIN-2 AND PROTEIN-4", Growth regulation, 5(1), 1995, pp. 45-52

Abstract

The aim of the present investigation was to study the role of the IGFsystem in the development of smooth muscle hypertrophy, Hypertrophy was initiated by partial ligation of the urethra in female Sprague-Dawley rats. The solution hybridization assay was used to analyse the mRNAlevels, Ligation of the urethra induced a sustained increase in bladder wet weight during the following 6-week period studied, IGF-I mRNA increased from 1 to 3 amol/mu gDNA 1-day after ligation, peaked at 3-days (4-fold), and normalized 6-weeks after ligation. In hypertrophying bladder, IGFBP-2 and -4 mRNA increased sharply during the first 10 days (5-fold) and remained elevated during the 6-week period. The IGF-I receptor mRNA did not change significantly. Removal of the obstruction 10 days after ligation caused a regression of bladder wet weight, and resulted in normalization of IGF-I, IGFBP-2 and -4 mRNA. The results show a close correlation between progression or regression of smooth muscle hypertrophy and differential regulation of IGF-I, IGFBP-2 and -4 mRNA, indicating that the IGF system may play a role in smooth muscle hypertrophy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 20:35:09