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Titolo:
DEPRESSION OF THALAMIC METABOLISM BY LORAZEPAM IS ASSOCIATED WITH SLEEPINESS
Autore:
VOLKOW ND; WANG GJ; HITZEMANN R; FOWLER JS; PAPPAS N; LOWRIMORE P; BURR G; PASCANI K; OVERALL J; WOLF AP;
Indirizzi:
BROOKHAVEN NATL LAB UPTON NY 11973 SUNY STONY BROOK,DEPT PSYCHIAT STONY BROOK NY 11794 VET ADM MED CTR NORTHPORT NY 00000 UNIV TEXAS HOUSTON TX 00000 BETH ISRAEL MED CTR NEW YORK NY 10003
Titolo Testata:
Neuropsychopharmacology
fascicolo: 2, volume: 12, anno: 1995,
pagine: 123 - 132
SICI:
0893-133X(1995)12:2<123:DOTMBL>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; CEREBRAL GLUCOSE-UTILIZATION; GABA-A RECEPTOR; BENZODIAZEPINE RECEPTORS; RAT-BRAIN; REGIONAL DISTRIBUTION; DIAZEPAM; SUBUNIT; ETHANOL; ALCOHOLICS;
Keywords:
BENZODIAZEPINES; POSITRON EMISSION TOMOGRAPHY; BRAIN GLUCOSE METABOLISM; SEDATION; THALAMUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
N.D. Volkow et al., "DEPRESSION OF THALAMIC METABOLISM BY LORAZEPAM IS ASSOCIATED WITH SLEEPINESS", Neuropsychopharmacology, 12(2), 1995, pp. 123-132

Abstract

Though it is well recognized that the pharmacological actions of benzodiazepines ave mediated by facilitation of GABAergic neurotransmission, the consequences of these changes in regional brain function are not well understood. This study measured regional brain glucose metabolism using Positron Emission Tomography and 2-deoxy-2[F-18]fluoro-D-glucose in normal controls (n = 21) investigated with and without lorazepam (30 mu g/kg IV) and with flumazenil given after lorazepam (n = 9). Lorazepam markedly decreased metabolism in thalamus (23 +/- 8%) and occipital cortex (19 +/- 8%), and flumazenil partially reversed these changes. Changes in metabolic activity in thalamus were significantly correlated with Iorazepam-induced sleepiness (r = .69, df 20, p < .0005) and there was a trend of an association between the reversal by flumazenil of lorazepam-induced change in thalamus and in sleepiness (r = .63, df 8, p = .07). Benzodiazepine-induced changes in thalamic activitymay account for their sedative properties.

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Documento generato il 20/01/20 alle ore 10:29:51