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Titolo:
THE EFFECT OF FOOD ON THE ABSORPTION OF C-14 SDZ FOX-988, AN ANTIDIABETIC AGENT, IN HEALTHY-HUMAN VOLUNTEERS
Autore:
LAU DTW; KALAFSKY G; TSE FLS;
Indirizzi:
SANDOZ PHARMACEUT CORP,SANDOZ RES INST,DEPT DRUG METAB & PHARMACOKINET,DRUG SAFETY E HANOVER NJ 07936 SANDOZ PHARMACEUT CORP,SANDOZ RES INST,DEPT DRUG METAB & PHARMACOKINET,DRUG SAFETY E HANOVER NJ 07936
Titolo Testata:
Biopharmaceutics & drug disposition
fascicolo: 3, volume: 16, anno: 1995,
pagine: 191 - 200
SICI:
0142-2782(1995)16:3<191:TEOFOT>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUCOSE-PRODUCTION; INHIBITION; INSULIN; ACIDS;
Keywords:
FAT; ABSORPTION; PHARMACOKINETICS; DIABETES; MAN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
11
Recensione:
Indirizzi per estratti:
Citazione:
D.T.W. Lau et al., "THE EFFECT OF FOOD ON THE ABSORPTION OF C-14 SDZ FOX-988, AN ANTIDIABETIC AGENT, IN HEALTHY-HUMAN VOLUNTEERS", Biopharmaceutics & drug disposition, 16(3), 1995, pp. 191-200

Abstract

The objective of this study is to examine the effect of food on oral absorption of SDZ FOX 988 (FOX 988), an antidiabetic agent, and circulating levels of its active metabolite, SDZ 53-450 (53-450). Sixteen normal volunteers received a single 10 mg dose of C-14-FOX 988, either as gelatin capsules or in a suspension (0.5% CMC). For subjects receiving each formulation, four subjects received a meal, consisting of 50% fat by calories, immediately following dosing, while the other Sour received the same meal at 2h post-dose. Serial blood, urine, and fecal samples were collected for 120h and analyzed for total radioactivity. Blood concentrations of 53-450 were analyzed using an HPLC-UV method. Concomitant administration with food increased the extent of FOX 988 absorption from either suspension or capsule, as shown by an increase inAUC and in urinary recovery of radioactivity. Blood concentrations of53-450 were only detected in subjects receiving food at dosing. No difference in absorption was observed between the capsule and the suspension. Results from this study showed that oral absorption of FOX 988 is enhanced by co-administration of food in normal volunteers.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 08:51:28