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Titolo:
INCREASE BY N-G-NITRO-L-ARGININE METHYL-ESTER (L-NAME) OF RESISTANCE TO VENOUS RETURN IN RATS
Autore:
WANG YX; LIM SL; PANG CCY;
Indirizzi:
UNIV BRITISH COLUMBIA,FAC MED,DEPT PHARMACOL & THERAPEUT,2176 HLTH SCI MALL VANCOUVER BC V6T 1Z3 CANADA UNIV BRITISH COLUMBIA,FAC MED,DEPT PHARMACOL & THERAPEUT VANCOUVER BCV6T 1Z3 CANADA
Titolo Testata:
British Journal of Pharmacology
fascicolo: 7, volume: 114, anno: 1995,
pagine: 1454 - 1458
SICI:
0007-1188(1995)114:7<1454:IBNM(O>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
CIRCULATORY FILLING PRESSURE; ENDOTHELIUM-DEPENDENT RELAXATION; RELAXING FACTOR; BLOOD-PRESSURE; ANGIOTENSIN-II; CONSCIOUS RATS; NERVE ACTIVITY; VASCULAR TONE; FEMORAL VEINS; OXIDE;
Keywords:
N-G-NITRO-L-ARGININE METHYL ESTER (L-NAME); NITRIC OXIDE; MEAN CIRCULATORY FILLING PRESSURE (MCFP); CARDIAC OUTPUT, TOTAL PERIPHERAL RESISTANCE, VENOUS RESISTANCE,CAPACITANCE VESSELS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
Y.X. Wang et al., "INCREASE BY N-G-NITRO-L-ARGININE METHYL-ESTER (L-NAME) OF RESISTANCE TO VENOUS RETURN IN RATS", British Journal of Pharmacology, 114(7), 1995, pp. 1454-1458

Abstract

1 The effects of the nitric oxide (NO) synthase inhibitor, N-G-nitro-L-arginine methyl ester (L-NAME), on mean circulatory filling pressure(MCFP), total peripheral resistance (TPR), cardiac output (CO) and resistance to venous return (R(v)) were studied in rats. 2 In conscious,unrestrained rats, L-NAME (0.5-16 mg kg(-1)) dose-dependently increased mean arterial pressure (MAP) but not MCFP, an inverse index of venous compliance, either in the absence of presence of the ganglionic blocker mecamylamine (10 mg kg(-1)). 3 In pentobarbitone-anaesthetized rats, L-NAME (2, 4, 8 mg kg(-1)) increased MAP and reduced CO in a dose-related manner but did not change MCFP. TPR (+84, +140 and +192%) as well as R(v) (+62, +72, +110%) were dose-dependently increased by L-NAME. 4 Our results show that L-NAME reduces CO by increasing arterial aswell as venous resistances. L-NAME does not affect MCFP.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 16:39:23