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Titolo:
LEFT-VENTRICULAR DYSFUNCTION - WHICH ROLE FOR CALCIUM-ANTAGONISTS
Autore:
ILICETO S;
Indirizzi:
UNIV CAGLIARI,INST CARDIOL,CATTEDRA CARDIOL,VIA SAN GIORGIO 12 CAGLIARI ITALY
Titolo Testata:
European heart journal
, volume: 18, anno: 1997, supplemento:, A
pagine: 87 - 91
SICI:
0195-668X(1997)18:<87:LD-WRF>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONGESTIVE-HEART-FAILURE; NO-REFLOW PHENOMENON; DILATED CARDIOMYOPATHY; MYOCARDIAL-INFARCTION; VERAPAMIL; NIFEDIPINE; MORTALITY; PROGNOSIS; DISEASE; THERAPY;
Keywords:
CALCIUM ANTAGONIST; CONGESTIVE HEART FAILURE; LEFT VENTRICULAR DYSFUNCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
S. Iliceto, "LEFT-VENTRICULAR DYSFUNCTION - WHICH ROLE FOR CALCIUM-ANTAGONISTS", European heart journal, 18, 1997, pp. 87-91

Abstract

Left ventricular dysfunction is the most common cause of congestive heart failure. Thus, treating or preventing left ventricular dysfunction represents an important therapeutic goal. The use of calcium antagonists in the treatment of left ventricular dysfunction or congestive heart failure has been proposed for many years now, mainly because of their potent vasodilatory effect. However, despite the theoretical basis, the results of studies exploring the possible use of calcium antagonists in this setting have not been at all encouraging. It has been suggested that this is because calcium antagonists have important additional effects: they depress cardiac contractility and activate the neurohormonal system. The various calcium antagonists have different characteristics and can be potentially useful in a variety of clinical conditions. Amlodipine (a calcium antagonist with a minimal cardiodepressant effect, long half-life and minimal activity on the neurohormonal system) has been shown to be clinically useful in congestive heart failure of non-ischaemic origin. Calcium antagonists capable of limiting heart rate increment are useful in limiting ischaemia-induced left ventricular dysfunction. Verapamil exerts a potent protective effect on bothmicrovascular damage and mechanical recovery during prolonged ischaemia followed by reperfusion. Lastly, nisoldipine is capable of ameliorating left ventricular function in patients with left ventricular diastolic dysfunction and has, therefore, potential in the treatment of congestive heart failure of left ventricular diastolic dysfunction origin. Thus, calcium antagonists may have a role in the treatment of left ventricular dysfunction provided that patient characteristics, the underlying mechanisms of the left ventricular dysfunction and the various calcium antagonist characteristics are well understood and carefully considered.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 14:38:35