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Titolo:
THE EFFECT OF FISH-OIL ON BLOOD-PRESSURE AND HIGH-DENSITY LIPOPROTEIN-CHOLESTEROL LEVELS IN PHASE-I OF THE TRIALS OF HYPERTENSION PREVENTION
Autore:
SACKS FM; HEBERT P; APPEL LJ; BORHANI NO; APPLEGATE WB; COHEN JD; CUTLER JA; KIRCHNER KA; KULLER LH; ROTH KJ; TAYLOR JO; HENNEKENS CH;
Indirizzi:
HARVARD UNIV,SCH PUBL HLTH,DEPT NUTR,665 HUNTINGTON AVE BOSTON MA 02115 BRIGHAM & WOMENS HOSP,CHANNING LAB BOSTON MA 02115 BRIGHAM & WOMENS HOSP,DEPT MED,DIV PREVENT MED BOSTON MA 02115 HARVARD UNIV,SCH MED BOSTON MA 00000 JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH BALTIMORE MD 00000 JOHNS HOPKINS UNIV,SCH MED BALTIMORE MD 00000 UNIV CALIF DAVIS DAVIS CA 95616 UNIV TENNESSEE MEMPHIS TN 00000 ST LOUIS UNIV ST LOUIS MO 63103 NHLBI BETHESDA MD 20892 UNIV MISSISSIPPI JACKSON MS 39216 UNIV PITTSBURGH,SCH PUBL HLTH PITTSBURGH PA 15260 E BOSTON NEIGHBORHOOD HLTH CTR BOSTON MA 00000
Titolo Testata:
Journal of hypertension
, volume: 12, anno: 1994, supplemento:, 7
pagine: 23 - 31
SICI:
0263-6352(1994)12:<23:TEOFOB>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
N-3 FATTY-ACIDS; INSULIN-DEPENDENT DIABETICS; SERUM-LIPIDS; DIETARY FISH; CARDIOVASCULAR-DISEASE; CLINICAL-CHEMISTRY; PLATELET-FUNCTION; HEART-DISEASE; BLEEDING-TIME; HEALTHY-MEN;
Keywords:
DIETARY FATS; POLYUNSATURATED FATTY ACIDS; FISH OILS; BLOOD PRESSURE; LIPOPROTEINS; CLINICAL TRIAL; HYPERTENSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
59
Recensione:
Indirizzi per estratti:
Citazione:
F.M. Sacks et al., "THE EFFECT OF FISH-OIL ON BLOOD-PRESSURE AND HIGH-DENSITY LIPOPROTEIN-CHOLESTEROL LEVELS IN PHASE-I OF THE TRIALS OF HYPERTENSION PREVENTION", Journal of hypertension, 12, 1994, pp. 23-31

Abstract

Objective: To study the effects of moderate doses of fish oil on blood pressure and high-density lipoprotein (HDL)-cholesterol. Methods Theparticipants were 350 normotensive men and women aged 30-54 years whowere enrolled from seven academic medical centers in phase I of the Trials of Hypertension Prevention. They were randomly assigned to receive placebo or 6 g purified fish oil once a day, which supplied 3 g n-3polyunsaturated fatty acids for 6 months. Results: Baseline blood pressure was (mean+/-SD) 123 +/- 9/81 +/- 5 mmHg. The mean differences inthe blood pressure changes between the fish oil and placebo groups were not statistically significant. There was no tendency for fish oil to reduce blood pressure more in subjects with baseline blood pressuresin the upper versus the lower quartile (132/87 versus 114/75 mmHg), low habitual fish consumption (0.4 versus 2.9 times a week) or low baseline plasma levels of n-3 fatty acids. Fish oil increased HDL(2)-cholesterol significantly compared with the placebo group. Subgroup analysis showed this effect to be significant in the women but not in the men. Increases in serum phospholipid n-3 fatty acids were significantly correlated with increases in HDL(2)-cholesterol and decreases in systolic blood pressure. Conclusion: Moderate amounts of fish oil (6 g/day) are unlikely to lower blood pressure in normotensive persons, but may increase HDL(2)-cholesterol, particularly in women.

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Documento generato il 01/12/20 alle ore 10:27:34