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Titolo:
ALPHA-ADRENERGIC PATHWAYS IN THE LATERAL HYPOTHALAMUS ARE IMPORTANT FOR THE DIPSOGENIC EFFECT OF CARBACHOL INJECTED INTO THE MEDIAL SEPTAL AREA
Autore:
CALLERA JC; SAAD WA; CAMARGO LAA; MENANI JV; RENZI A; ABRAOSAAD W;
Indirizzi:
UNIV ESTADUAL PAULISTA,FAC ODONTOL,DEPT CIENCIAS FISIOL,RUA HUMAITA 1680 BR-14801903 ARARAQUARA SP BRAZIL UNIV ESTADUAL PAULISTA,FAC ODONTOL,DEPT CIENCIAS FISIOL BR-14801903 ARARAQUARA SP BRAZIL UNIV SAO PAULO,FAC MED,DEPT CIRURGIA BR-01246903 SAO PAULO BRAZIL
Titolo Testata:
Brazilian journal of medical and biological research
fascicolo: 2, volume: 28, anno: 1995,
pagine: 240 - 245
SICI:
0100-879X(1995)28:2<240:APITLH>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANGIOTENSIN-II; WATER-INTAKE; CHOLINERGIC STIMULATION; NATRIURETIC RESPONSES; SATIATED RAT; DRINKING; CLONIDINE; ALPHA-2-ADRENOCEPTORS; PRESSOR; ALPHA-1-ADRENOCEPTORS;
Keywords:
LATERAL HYPOTHALAMUS; SEPTAL AREA; A(1)- AND A(2)-ADRENOCEPTORS; CHOLINERGIC RECEPTORS; WATER INTAKE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
J.C. Callera et al., "ALPHA-ADRENERGIC PATHWAYS IN THE LATERAL HYPOTHALAMUS ARE IMPORTANT FOR THE DIPSOGENIC EFFECT OF CARBACHOL INJECTED INTO THE MEDIAL SEPTAL AREA", Brazilian journal of medical and biological research, 28(2), 1995, pp. 240-245

Abstract

We studied the effect of the alpha(1)- and alpha(2)-adrenergic receptors of the lateral hypothalamus (LH) on the control of water intake induced by injection of carbachol into the medial septal area (MSA) of adult male Holtzman rats (250-300 g) implanted with chronic stainless steel cannulae into the LH and MSA. The volume of injection was always 1 mu l and was injected over a period of 30-60 s. For control, 0.15 M NaCl was used. Clonidine (20 nmol) but not phenylephrine (160 nmol) injected into the LH inhibited water intake induced by injection of carbachol (2 nmol) into the MSA, from 5.4 +/- 1.2 ml/h to 0.3 +/- 0.1 and 3.0 +/- 0.9 ml/h, respectively (N = 26). When we injected yohimbine (80 nmol) + clonidine (20 nmol) and prazosin (40 nmol) + clonidine (20 nmol) into theLH, water intake induced by injection of carbachol into the MSA was inhibited from 5.4 +/- 1.2 ml/h to 0.8 +/- 0.5 and 0.3 +/- 0.2 ml/h, respectively (N = 19). Water intake induced by carbachol (2 nmol) injected into the MSA was decreased by previous injection of yohimbine (80 nmol) + phenylephrine (160 nmol) and prazosin (40 nmol) + phenylephrine (l60 nmol) from 5.4 +/- 1.2 ml/h to 1.0 +/- 0.7 and 1.8 +/- 0.8 ml/h, respectively (N = 16). The cannula reached both the medial septal area in its medial portion and the lateral hypothalamus. It has been suggested that the different pathways for induction of drinking converge on a final common pathway. Thus, adrenergic stimulation of alpha(2),-adrenoceptors ofLH can influence this final common pathway.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 16:15:48