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Titolo:
INCREASED PITUITARY GROWTH HORMONE-RELEASING FACTOR (GRF) RECEPTOR MESSENGER-RIBONUCLEIC-ACID EXPRESSION IN FOOD-DEPRIVED RATS
Autore:
SUGIHARA H; EMOTO N; SHIBASAKI T; MINAMI S; WAKABAYASHI I;
Indirizzi:
NIPPON MED COLL,DEPT MED,BUNKYO KU,1-1-5 SENDAGI TOKYO 113 JAPAN
Titolo Testata:
Brain research
fascicolo: 1-2, volume: 742, anno: 1996,
pagine: 355 - 358
SICI:
0006-8993(1996)742:1-2<355:IPGHF(>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
FACTOR BINDING; CELLS; GLUCOCORTICOIDS; CULTURE; RHYTHM;
Keywords:
GROWTH HORMONE-RELEASING FACTOR (GRF); GRF RECEPTOR; RAT; FOOD DEPRIVATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
H. Sugihara et al., "INCREASED PITUITARY GROWTH HORMONE-RELEASING FACTOR (GRF) RECEPTOR MESSENGER-RIBONUCLEIC-ACID EXPRESSION IN FOOD-DEPRIVED RATS", Brain research, 742(1-2), 1996, pp. 355-358

Abstract

In prolonged food-deprived rats, growth hormone (CH) secretion in response to exogenous GH-releasing factor (GRF) is enhanced both in vivo and in vitro. We tested the hypothesis that, in fasted rats, GRF receptors in the pituitary may be up-regulated. The expression of mRNA for the GRF receptor in the pituitary and GRF binding to the pituitary membrane were examined in adult male Wistar rats deprived of food for 72 h. The level of GRF receptor mRNA in the pituitary was significantly increased after 48 h food deprivation and was more than 3 times the level in control rats after 72 h food deprivation. GRF binding to the pituitary was significantly increased after 72 h food deprivation. The results of the present study provide evidence regarding changes in the GH axis in fasted rats, involving increased pituitary responsiveness toGRF and an increase in the pituitary membrane GRF receptor concentration.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 11:32:38