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Titolo:
TRANSPORT PATHWAYS IN THE MALARIA-INFECTED ERYTHROCYTE - CHARACTERIZATION AND THEIR USE AS POTENTIAL TARGETS FOR CHEMOTHERAPY
Autore:
GINSBURG H;
Indirizzi:
HEBREW UNIV JERUSALEM,INST LIFE SCI,DEPT BIOL CHEM IL-91904 JERUSALEMISRAEL
Titolo Testata:
Memorias do Instituto Oswaldo Cruz
, volume: 89, anno: 1994, supplemento:, 2
pagine: 99 - 109
SICI:
0074-0276(1994)89:<99:TPITME>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
RED-BLOOD-CELLS; PARASITE PLASMODIUM-FALCIPARUM; PERMEATION PATHWAYS; HOST ERYTHROCYTE; PHOSPHOLIPID ANALOGS; MONKEY ERYTHROCYTES; KNOWLESI INFECTION; CALCIUM-TRANSPORT; INVITRO CULTURES; PLASMA-MEMBRANES;
Keywords:
MALARIA; ERYTHROCYTE; CHEMOTHERAPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
82
Recensione:
Indirizzi per estratti:
Citazione:
H. Ginsburg, "TRANSPORT PATHWAYS IN THE MALARIA-INFECTED ERYTHROCYTE - CHARACTERIZATION AND THEIR USE AS POTENTIAL TARGETS FOR CHEMOTHERAPY", Memorias do Instituto Oswaldo Cruz, 89, 1994, pp. 99-109

Abstract

The intraerythrocytic malarial parasite is involved in an extremely intensive anabolic activity while it resides in its metabolically quiescent host cell. The necessary fast uptake of nutrients and the discharge of waste product, are guaranteed by parasite-induced alterations ofthe constitutive transporters of the host cell and the production of new parallel pathways. The membrane of the host cell thus becomes permeable to phospholipids, purine bases and nucleosides, small non-electrolytes anions and cations. When the new pathways are quantitatively unimportant, classical inhibitors of native transporters can be used to inhibit parasite growth Several compounds were found to effectively inhibit the new pathways and consequently, parasite growth. The pathwayshave also been used to introduce cytotoxic agents. The parasitophorous membrane consists of channels which ape highly permeable to small solutes and display no ion selectivity. Transport of some cations and anions across the parasite membrane is rapid and insensitive to classical inhibitors, and in some cases it is mediated by specific antiporterswhich respond to their respective inhibitors. Macromolecules have been shown to Peach the parasitophorous space through a duct contiguous with the host cell membrane, and subsequently to be endocytosed at the parasite membrane. The simultaneous presence of the parasitophorous membrane channels and the duct, however, is incompatible with experimental evidences. No specific inhibitors were found as yet that would efficiently inhibit transport through the channels or the duct.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 20:00:12