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Titolo:
EFFECT OF MICROINJECTION OF MUSCIMOL INTO THE DORSOMEDIAL OR PARAVENTRICULAR HYPOTHALAMIC NUCLEUS ON AIR STRESS-INDUCED NEUROENDOCRINE AND CARDIOVASCULAR CHANGES IN RATS
Autore:
STOTZPOTTER EH; MORIN SM; DIMICCO JA;
Indirizzi:
INDIANA UNIV,SCH MED,DEPT PHARMACOL & TOXICOL,635 BARNHILL DR INDIANAPOLIS IN 46202 INDIANA UNIV,SCH MED,DEPT PHARMACOL & TOXICOL INDIANAPOLIS IN 46202 INDIANA UNIV,SCH MED,PROGRAM MED NEUROBIOL INDIANAPOLIS IN 46202
Titolo Testata:
Brain research
fascicolo: 1-2, volume: 742, anno: 1996,
pagine: 219 - 224
SICI:
0006-8993(1996)742:1-2<219:EOMOMI>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING-FACTOR; AMINO-ACID RECEPTORS; FACTOR (CRF)-LIKE IMMUNOREACTIVITY; PLUS-MAZE TEST; POSTERIOR HYPOTHALAMUS; INDUCED TACHYCARDIA; REGULATE ANXIETY; MEDIAN-EMINENCE; CONSCIOUS RATS; GABA RECEPTORS;
Keywords:
ADRENOCORTICOTROPIC HORMONE (ACTH); STRESS; DORSOMEDIAL HYPOTHALAMUS; PARAVENTRICULAR NUCLEUS; HEART RATE; BLOOD PRESSURE; MUSCIMOL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
E.H. Stotzpotter et al., "EFFECT OF MICROINJECTION OF MUSCIMOL INTO THE DORSOMEDIAL OR PARAVENTRICULAR HYPOTHALAMIC NUCLEUS ON AIR STRESS-INDUCED NEUROENDOCRINE AND CARDIOVASCULAR CHANGES IN RATS", Brain research, 742(1-2), 1996, pp. 219-224

Abstract

The paraventricular nucleus (PVN) contains neurons that release corticotrophin-releasing factor (CRH) and thus provide the stimulus for therelease of adrenocorticotrophic hormone (ACTH), the neuroendocrine hallmark of the response to stress. However, inhibition of neuronal activity in the nearby dorsomedial hypothalamic nucleus (DMH) by microinjection of the GABA(A) receptor agonist muscimol suppresses cardiovascular changes seen in air stress in conscious rats, while similar treatment in the PVN has no effect. Because the DMH projects to the PVN and also contains CRH neurons, we decided to investigate the role of neuronal activity in the DMH in the neuroendocrine response to stress. In control rats or after microinjection of saline vehicle into either the PVN or the DMH, air stress resulted in equivalent increases in plasma levels of ACTH, heart rate, and arterial pressure. Bilateral microinjection of muscimol 80 pmol/100 nl/side into either the PVN or the DMH prior to air stress reduced the associated increases in plasma ACTH (-37% and -71%, respectively), while only injection into the DMH attenuated the accompanying tachycardia (-62%) and presser (-83%) effects. Thus, neurons in the DMH, but not in the PVN, play a role in both the cardiovascular and neuroendocrine response to air stress.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 07:57:32