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Titolo:
CORONAVIRUS-INDUCED ENCEPHALOMYELITIS - BALANCE BETWEEN PROTECTION AND IMMUNE PATHOLOGY DEPENDS ON THE IMMUNIZATION SCHEDULE WITH SPIKE PROTEIN-S
Autore:
FLORY E; STUHLER A; BARACLATAS V; LASSMANN H; WEGE H;
Indirizzi:
FED RES CTR VIRUS DIS ANIM,FRIEDRICH LOEFFLER INST D-17498 INSEL RIEMS GERMANY FED RES CTR VIRUS DIS ANIM,FRIEDRICH LOEFFLER INST D-17498 INSEL RIEMS GERMANY UNIV WURZBURG,INST VIROL & IMMUNBIOL D-97078 WURZBURG GERMANY UNIV VIENNA,INST NEUROL A-1090 VIENNA AUSTRIA
Titolo Testata:
Journal of General Virology
, volume: 76, anno: 1995,
parte:, 4
pagine: 873 - 879
SICI:
0022-1317(1995)76:<873:CE-BBP>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; MOUSE HEPATITIS-VIRUS; CD8+ T-CELLS; DEMYELINATING ENCEPHALOMYELITIS; MONOCLONAL-ANTIBODIES; NUCLEOCAPSID PROTEIN; MEDIATED CLEARANCE; LYMPHOCYTES-T; STRAIN-JHM; RATS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
E. Flory et al., "CORONAVIRUS-INDUCED ENCEPHALOMYELITIS - BALANCE BETWEEN PROTECTION AND IMMUNE PATHOLOGY DEPENDS ON THE IMMUNIZATION SCHEDULE WITH SPIKE PROTEIN-S", Journal of General Virology, 76, 1995, pp. 873-879

Abstract

The neurotropic mouse hepatitis virus MHV-JHM induces central nervoussystem (CNS) demyelination in Lewis rats that pathologically resembles CNS lesions in multiple sclerosis. The mechanisms of MHV-JHM-induceddemyelination remain unclear and several studies have implicated the role of the immune response in this process. We have shown previously that protective immunity against MHV-JHM-induced encephalomyelitis wasinduced by immunization with a vaccinia virus (VV) recombinant expressing MHV-JHM S-protein (W-S). Here, we present evidence that the time of MHV-JHM challenge after immunization with W-S plays a critical rolein protective immunity. The induction of virus-neutralizing S-protein-specific antibodies prior to the MHV-JHM challenge modulates the disease process and a subacute encephalomyelitis based on a persistent virus infection developed. Typical pathological alterations were lesions of inflammatory demyelination. In addition, the results indicate that after seroconversion, CD8(+) T cells were no longer essential for virus elimination in contrast to their role in protection during acute encephalomyelitis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 20:33:54