Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ROLE OF GLUCOSE IN REGULATING THE BRAIN AND COGNITION
Autore:
GOLD PE;
Indirizzi:
UNIV VIRGINIA,DEPT PSYCHOL,102 GILMER HALL CHARLOTTESVILLE VA 22903 UNIV VIRGINIA,GRAD PROGRAM NEUROSCI CHARLOTTESVILLE VA 22903
Titolo Testata:
The American journal of clinical nutrition
fascicolo: 4, volume: 61, anno: 1995, supplemento:, S
pagine: 987 - 995
SICI:
0002-9165(1995)61:4<987:ROGIRT>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
AGED FISCHER-344 RATS; MEMORY DEFICITS; ELDERLY HUMANS; SPONTANEOUS-ALTERNATION; SPATIAL INFORMATION; SENILE DEMENTIA; ENHANCEMENT; INJECTIONS; MICE; PERFORMANCE;
Keywords:
GLUCOSE; MEMORY; LEARNING; COGNITION; AGING; ACETYLCHOLINE; OPIATES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
75
Recensione:
Indirizzi per estratti:
Citazione:
P.E. Gold, "ROLE OF GLUCOSE IN REGULATING THE BRAIN AND COGNITION", The American journal of clinical nutrition, 61(4), 1995, pp. 987-995

Abstract

Extensive evidence indicates that relatively modest increases in circulating glucose concentrations enhance learning and memory processes in rodents and humans. In rats, systemic injections of glucose enhance learning and memory under many conditions. When microinjected into specific brain sites, glucose has selective behavioral and pharmacological effects, with behavioral effects that are specific to the brain siteinjected and pharmacological effects that are largely specific to interactions with opiate agonists. Recent evidence suggests that glucose may attenuate opiate inhibition of acetylcholine release in the hippocampus. The relative safety of glucose has permitted tests of glucose effects on cognitive functions in humans. Glucose also enhances learning and memory in healthy aged humans and enhances several other cognitive functions in subjects with severe cognitive pathologies, including individuals with Alzheimer's disease and Down syndrome. Thus, increases in circulating glucose concentrations have robust and broad influences on brain functions that span many neural and behavioral measures and cross readily from rodents to humans.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 13:49:13