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Titolo:
THE EFFECTS OF THIOPENTONE, ETOMIDATE, KETAMINE AND MIDAZOLAM ON SEVERAL BACTERICIDAL FUNCTIONS OF POLYMORPHONUCLEAR LEUKOCYTES IN-VITRO
Autore:
KRUMHOLZ W; DEMEL C; JUNG S; MEUTHEN G; KNECHT J; HEMPELMANN G;
Indirizzi:
UNIV GIESSEN,DEPT ANAESTHESIOL & INTENS CARE MED,KLIN STR 29 D-35392 GIESSEN GERMANY
Titolo Testata:
European journal of anaesthesiology
fascicolo: 2, volume: 12, anno: 1995,
pagine: 141 - 146
SICI:
0265-0215(1995)12:2<141:TEOTEK>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Keywords:
ANESTHETICS INTRAVENOUS; ETOMIDATE; KETAMINE; MIDAZOLAM; THIOPENTONE, BLOOD; LEUKOCYTES; IMMUNE RESPONSE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
NO
Recensione:
Indirizzi per estratti:
Citazione:
W. Krumholz et al., "THE EFFECTS OF THIOPENTONE, ETOMIDATE, KETAMINE AND MIDAZOLAM ON SEVERAL BACTERICIDAL FUNCTIONS OF POLYMORPHONUCLEAR LEUKOCYTES IN-VITRO", European journal of anaesthesiology, 12(2), 1995, pp. 141-146

Abstract

Polymorphonuclear leucocytes(PMNL) are an essential component of the defence system against invading bacteria. There is evidence that some anaesthetics a re able to suppress PMNL functions, promoting, perhaps,perioperative infection. We studied the effects of thiopentone, etomidate, ketamine, and midazolam on the generation of bactericidal agents(superoxide anion, hydrogen peroxide, and myeloperoxidase) by PMNL invitro. Thiopentone inhibited superoxide anion (P less than or equal to 0.01) as well as hydrogen peroxide production (P less than or equal to 0.001). However, there was no statistically significant effect on myeloperoxidase release. Neither etomidate nor ketamine influenced the PMNL functions tested to any extent. Midazolam suppressed superoxide anion generation (P less than or equal to 0.01) but only if a concentration far beyond clinical relevance was used.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 04:32:53