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Titolo:
P57(KIP2), A STRUCTURALLY DISTINCT MEMBER OF THE P21(CIP1) CDK INHIBITOR FAMILY, IS A CANDIDATE TUMOR-SUPPRESSOR GENE
Autore:
MATSUOKA S; EDWARDS MC; BAI C; PARKER S; ZHANG PM; BALDINI A; HARPER JW; ELLEDGE SJ;
Indirizzi:
BAYLOR COLL MED,HOWARD HUGHES MED INST HOUSTON TX 77030 BAYLOR COLL MED,HOWARD HUGHES MED INST HOUSTON TX 77030 BAYLOR COLL MED,VERNA & MARRS MCLEAN DEPT BIOCHEM HOUSTON TX 77030 BAYLOR COLL MED,DEPT HUMAN & MOLEC GENET HOUSTON TX 77030
Titolo Testata:
Genes & development
fascicolo: 6, volume: 9, anno: 1995,
pagine: 650 - 662
SICI:
0890-9369(1995)9:6<650:PASDMO>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
WIEDEMANN-BECKWITH SYNDROME; CYCLIN-DEPENDENT KINASES; RETINOBLASTOMA PROTEIN; CELL-CYCLE; CATALYTIC SUBUNIT; P21;
Keywords:
P57(KIP2); P21(CIP1); CDK INHIBITOR; TUMOR SUPPRESSOR; CELL CYCLE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
S. Matsuoka et al., "P57(KIP2), A STRUCTURALLY DISTINCT MEMBER OF THE P21(CIP1) CDK INHIBITOR FAMILY, IS A CANDIDATE TUMOR-SUPPRESSOR GENE", Genes & development, 9(6), 1995, pp. 650-662

Abstract

Cydin-dependent kinases (Cdks) are positive regulators of cell proliferation, whereas Cdk inhibitors (CKIs) inhibit proliferation. We describe a new CKI, p57(KIP2), which is related to p21(CIP1) and p27(KIP1).p57(KIP2) is a potent, tight-binding inhibitor of several G(1) cyclin/Cdk complexes, and its binding is cyclin dependent. Unlike CIP1, KIP2is not regulated by p53. Overexpression of p57(KIP2) arrests cells inG(1). p57(KIP2) proteins have a complex structure. Mouse p57(KIP2) consists Of four structurally distinct domains: an amino-terminal Cdk inhibitory domain, a proline-rich domain, an acidic-repeat region, and acarboxy-terminal domain conserved with p27(KIP1). Human p57(KIP2) appears to have conserved the amino- and carboxy-terminal domains but hasreplaced the internal regions with sequences containing proline-alanine repeats. In situ hybridization during mouse embryogenesis revealed that KIP2 mRNA displays a striking pattern of expression during development, showing high level expression in skeletal muscle, brain, heart,lungs, and eye. Most of the KIP2-expressing cells are terminally differentiated, suggesting that p57(KIP2) is involved in decisions to exitthe cell cycle during development and differentiation. Human KIP2 is located at 11p15.5, a region implicated in both sporadic cancers and Beckwith-Wiedemann syndrome, a familial cancer syndrome, marking it as a candidate tumor suppressor. The discovery of a new member of the p21(CIP1) inhibitor family with novel structural features and expression patterns suggests a complex role for these proteins in cell cycle control and development.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 14:54:49