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Titolo:
OCTACOSANOL AFFECTS LIPID-METABOLISM IN RATS FED ON A HIGH-FAT DIET
Autore:
KATO S; KARINO KI; HASEGAWA S; NAGASAWA J; NAGASAKI A; EGUCHI M; ICHINOSE T; TAGO K; OKUMORI H; HAMATANI K; TAKAHASHI M; OGASAWARA J; MASUSHIGE S; HASEGAWA T;
Indirizzi:
TOKYO UNIV AGR & TECHNOL,FAC AGR,DEPT AGR CHEM,SETAGAYA KU TOKYO 156 JAPAN SUMITOMO SEIKA CHEM CO L,CHUO KU OSAKA 541 JAPAN
Titolo Testata:
British Journal of Nutrition
fascicolo: 3, volume: 73, anno: 1995,
pagine: 433 - 441
SICI:
0007-1145(1995)73:3<433:OALIRF>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
TISSUES;
Keywords:
OCTACOSANOL; LIPID METABOLISM; ADIPOSE TISSUE; SERUM TRIACYLGLYCEROL; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
S. Kato et al., "OCTACOSANOL AFFECTS LIPID-METABOLISM IN RATS FED ON A HIGH-FAT DIET", British Journal of Nutrition, 73(3), 1995, pp. 433-441

Abstract

The effect of dietary octacosanol, a long-chain alcohol, on lipid metabolism was investigated in rats fed on a high-fat diet for 20 d. The addition of octacosanol (10 g/kg diet) to the high-fat diet led to a significant reduction (P < 0.05) in the perirenal adipose tissue weightwithout decrease of the cell number, suggesting that octacosanol may suppress lipid accumulation in this tissue, whereas no effect was seenin the epididymal adipose tissue weight and in the lipid content in liver. Octacosanol supplementation decreased the serum triacylglycerol concentration, and enhanced the concentration of serum fatty acids, probably through inhibition of hepatic phosphatidate phosphohydrolase (EC 3.1.3.4). Though the activity of hormone-sensitive lipase (EC 3.1.1.3) was not influenced by octacosanol, higher activities of lipoproteinlipase (EC 3.1.1.34) in the perirenal adipose tissue and the total oxidation rate of fatty acid in muscle were observed. Lipid absorption was not affected by the inclusion of octacosanol. Thus, the present results suggest that the dietary incorporation of octacosanol into a high-fat diet affects some aspects of lipid metabolism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 12:51:28