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Titolo:
METAPHASE ARREST IN NEWLY MATURED OR MICROTUBULE-DEPLETED MOUSE EGGS AFTER CALCIUM STIMULATION
Autore:
MOSES RM; MASUI Y;
Indirizzi:
UNIV TORONTO,DEPT ZOOL,25 HARBORD ST TORONTO ON M5S 1A1 CANADA
Titolo Testata:
Zygote
fascicolo: 1, volume: 3, anno: 1995,
pagine: 1 - 8
SICI:
0967-1994(1995)3:1<1:MAINMO>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Keywords:
6-DIMETHYLAMINOPURINE; METAPHASE ARREST; MICROTUBULE INHIBITORS; NEWLY MATURED MOUSE EGGS; PROTEIN SYNTHESIS INHIBITORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
NO
Recensione:
Indirizzi per estratti:
Citazione:
R.M. Moses e Y. Masui, "METAPHASE ARREST IN NEWLY MATURED OR MICROTUBULE-DEPLETED MOUSE EGGS AFTER CALCIUM STIMULATION", Zygote, 3(1), 1995, pp. 1-8

Abstract

In mouse eggs arrested at meiotic metaphase II, the increase in intracellular calcium that results from fertilisation induces nuclear formation in both newly ovulated and older eggs. In contrast, the calcium increase that results from exposure to the calcium ionophore A23187 induces nuclear formation in older, but not young, newly ovulated eggs. When treated with the microtubule inhibitor colcemid, and fertilised, young eggs remained at metaphase, but many older eggs formed nuclei, although older eggs treated with colcemid and A23187 remained at metaphase. However, young A23187-treated eggs, young colcemid-treated fertilised eggs, and older colcemid- and A23187-treated eggs, formed nuclei when treated, in addition, with the protein synthesis inhibitor cycloheximide, or the protein kinase inhibitor 6-dimethylaminopurine (6-DMAP). The possibility is discussed that metaphase in newly matured eggs and microtubule-depleted eggs may be maintained by similar mechanisms involving short-lived phosphorylated proteins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 14:36:59